針對台灣海域所採集的軟珊瑚Sinularia sp.和Sinularia lochmodes 所具有的化學成分研究中，共分離出10個天然化合物。於Sinularia sp.中共分離出4個新的天然化合物分別為1α,3β-dihydroxy-24S-methylcholesta-5,9-
diene (1)、1α,3β-dihydroxy-24-methylenecholesta-5-ene (2)、1α,3β-dihydroxy-
24S-methylcholesta-5-ene (3)、sinularioperoxide E (4)，與四個已知化合物分別
為7-isopropenyl -1,4a-dimethyl-decahydro-naphthalen-1-ol (5)、β-dictyopterol (6)、N-(4-hydroxyphenethyl)-3-methyldodecanamide (7)、(Z)-N-[2-(4-
hydroxyphenyl)ethyl]-3-methyldodec-2-enamide (8)。從軟珊瑚Sinularia lochmodes共分離出2個新的化合物lochmolin A (9)和lochmolin B (10)。化合物1–10之化學結構是以各種光譜(1D NMR、2D NMR、IR及MS)的方法加以確定。在生物活性測試方面，化合物2-6亦進行抗發炎活性測試。

The chemical constituents of organic extracts of the Formosan soft
corals Sinularia sp. and Sinularia lochmodes were studied. Investigation on Sinularia sp. has led to the isolation of eight compounds (1-8), including four new compounds, 1α,3β-dihydroxy-24S-methylcholesta-5,9-diene (1), 1α,3β-dihydroxy-24-methylencholesta-5-ene (2), 1α,3β-dihydroxy
-24S-methylcholesta-5-ene (3), sinularioperoxide E (4), and four known compounds, 7-isopropenyl-1,4a-dimethyl-decahydro-naphthalen-1-ol (5), β-dictyopterol (6), N-(4-hydroxyphenethyl)-3-methyldodecanamide (7), (Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-methyldodec-2-enamide (8). Also, investigation on the chemical constituent of Sinularia lochmodes has led to the isolation of two new compounds, lochmolin A (9) and lochmolin B (10). The structures of 1–10 were elucidated by spectroscopic evidences
(1D NMR, 2D NMR, IR, and MS). The activity of compounds 2-6 to inhibit the pro-inflammatory iNOS and COX-2 protein expression of LPS-stimulated
RAW-264.7 macrophage cells have been estimated.

中文摘要 1
英文摘要 2
壹、緒論 5
第一節: 研究動機及目的 5
第二節 : 台灣產指形軟珊瑚Sinularia屬的文獻回顧7
貳、材料與方法 18
第一節:實驗設備儀器 18
第二節:實驗材料 19
第三節:生物樣品採集時間、地點與分類地位 20
第四節:萃取與分離純化步驟 22
參、結果與討論 26
一、指形軟珊瑚Sinularia sp.所分離化合物之結構解析26

(一)、1α,3β-Dihydroxy-24S-methylcholesta-5,9-diene
(1)之結構解析 26
(二)、1α,3β-Dihydroxy-24-methylenecholesta-5-ene
(2)之結構解析 40
(三)、1α,3β-Dihydroxy-24S-methylcholesta-5-ene
(3)之結構解析 54
(四)、Sinularioperoxide E (4)之結構解析 68
(五)、7-Isopropenyl-1,4a-dimethyl-decahydro-
naphthalen-1-ol (5)之結構解析 82
(六)、β-Dictyopterol (6)之結構解析 88
(七)、N-(4-Hydroxyphenethyl)-3 methyldodecanamide(7)之結構解析 93
(八)、(Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-
methyldodec-2-enamide(8)之結構解析 99
二、叢指形軟珊瑚Sinularia lochmodes所分離化合物
之結構解析105

(九)、Lochmolin A之結構解析 105
(十)、Lochmolin B之結構解析 120
肆、生物活性之研究 134
一、抗發炎活性檢測方法 134
二、抗發炎活性檢驗結果 136
伍、結論 138
陸、參考文獻 140

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