利用α-磺酸基醯胺與α,β-不飽和酯分別進行〔3+2〕環合加成反應與〔3+3〕環合加成反應後，可分別得到含氮五員環的麩胺酸酯與含氮六員環的環戊亞醯胺，再將其應用到吡咯啶骨架、泰洛弗啉、奎特普啉和駢雙環的環戊亞醯胺之合成研究。

Reaction of 3-sulfonyl acetamides with various substituted methyl acrylate derivatives furnished pyroglutamate and glutarimidess via [3+2] and [3+3] cycloaddition respectively. The results were applied to the synthesis of pyrrolizidine skeleton, tylophorine, cryptopleurine and fused bicyclic glutarimides.

第一章：吡咯啶骨架之合成研究
一、前言……………………………………………………………01
二、結果與討論……………………………………………………10
三、結論……………………………………………………………22
第二章：泰洛弗啉和奎特普啉的合成研究
一、前言……………………………………………………………23
二、結果與討論……………………………………………………31
三、結論……………………………………………………………48
第三章：駢雙環的環戊亞醯胺之合成研究
一、前言……………………………………………………………50
二、結果與討論……………………………………………………52
三、結論……………………………………………………………62
第四章：實驗部份……………………………………………………63
第五章：參考文獻 …………………………………………………179
附錄：光譜資料 ……………………………………………………185

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10. Single-crystal X-ray structural determination: crystal of 69 was grown by slow diffusion of ethyl acetate into a solution of 69 in DCM to yield colorless prism. The compound crystallizes in the orthorhombic crystal system, space group. Pca21, a=9.8102(11) Å, b=10.3120(12) Å, c=18.686(2) Å, V=1890.3(4) Å3, Z=4, dcalcd=1.284 mg/m3, absorption coefficient 0.198 mm-1, F(000)=776, 2