本研究以養殖型紅藻海木耳(Sarcodia suieae)進行生物活性研究，早期研究中指出其具抗氧化及調整血糖的活性。首先對四個萃取層(DEE、DEH、DHE、DHH) 進行抗發炎、美白、促骨頭形成、細胞毒性進行篩選，發現DEE、DEH可以顯著抑制脂多醣(LPS)刺激大鼠巨噬細胞(macropage RAW 264.7)所產生發炎性蛋白質抑制誘導型一氧化氮合酶(iNOS)的生成，DEH、DHH有促進骨頭形成的效果及美白的效果，DEE、DEH、DHH、DHE對於人類前列腺癌細胞株有抑制的效果，DEE、DHE、DHH對於人類肝癌細胞株有抑制的效果。再對酒精萃取得到三個萃取層PD1、PD2、PD3進行抗發炎、促骨頭形成、美白活性、細胞毒性及神經保護的活性篩選。其中PD1可以顯著抑制脂多醣刺激大鼠巨噬細胞所產生發炎性蛋白質抑制誘導型一氧化氮合酶的生成，在神經保護測試中在SH-SY5Y人類神經母細胞瘤、斑馬魚類帕金森氏模式測試PD1皆具有神經保護作用。PD1、PD2、PD3對於腦癌細胞皆有抑制的現象，PD1、PD3對於肝癌細胞及正常肝細胞具有抑制成長現象，PD1、PD2、PD3同時也具有美白的活性。此外，大白鼠口服PD1具有顯著抑制鹿角菜膠(carrageenan)所誘導的大鼠足蹠腳掌腫脹產生發炎性疼痛(inflammatory pain)的行為包含機械性觸覺、熱覺過敏。從組織病理學上也觀察合併給予PD1抑制了鹿角菜膠所造成白血球浸潤、促發炎因子及過氧化的上升。此研究結果意味著 PD1 中可能具有發展成為抗發炎及止痛藥物的潛力。預期本研究結果能幫助科學家繼續開發海木耳的其它生醫應用價值及有助提升海木耳的經濟價值。

In this study, the biological activity of aquaculture red algae (Sarcodia suieae). Earlier studies indicated that it has antioxidant and glucose-regulating activity. First of all, four extraction layers (DEE, DEH, DHE, DHH) were selected for anti-inflammation, whitening, bone formation promotion and cytotoxicity screening. It was found that DEE and DEH significantly inhibited the production of inducible nitric oxide synthase (iNOS) by inflammatory proteins produced by macrophage RAW 264.7 stimulated by lipopolysaccharide (LPS), DEH and DHH can promote bone formation and whitening effect, DEE, DEH, DHH, DHE inhibit human prostate cancer cell lines, DEE, DHE, DHH inhibit the effect of human hepatoma cell lines, Then, three extraction layers PD1, PD2 and PD3 were extracted from the alcohol to screen out the anti-inflammatory, bone-forming, whitening, cytotoxic and neuroprotective activities, PD1 could significantly inhibit lipopolysaccharide stimulated inflammatory proteins produced by rat macrophages to inhibit the formation of inducible nitric oxide synthase, PD1 is neuroprotective in both SH-SY5Y human neuroblastoma and zebrafish Parkinson's mode in neuroprotection tests, PD1, PD2 and PD3 have inhibitory effects on brain cancer cells. PD1 and PD3 can inhibit the growth of hepatoma cells and normal liver cells. PD1, PD2 and PD3 also have the activity of whitening. In addition, the oral administration of PD1 to rats significantly inhibits the carrageenan-induced swelling of the paw of the plantar palpitations and induces inflammatory pain. These include mechanical tactile sensations, thermal hyperalgesia. Histopathology also observed that combined administration of PD1 inhibited the increase of leukocyte infiltration, proinflammatory cytokines and peroxidation caused by carrageenan. The results of this study suggest that PD1 may have the potential to develop anti-inflammatory and analgesic drugs. The results of this study are expected to help scientists continue to develop other biomedical applications of red algae and help to enhance the economic value of red algae.

論文審定書..........i
誌謝..........ii
中文摘要..........iii
縮寫..........vi
目錄..........viii
圖目錄..........x
表目錄..........xii
前言..........1
藻類的重要性..........1
海洋天然物的研究..........4
紅藻研究回顧..........6
發炎定義..........8
發炎反應之生理機制..........8
神經保護作用之離體模式探討..........13
海洋產物在化妝品上的運用..........15
脂多醣誘發小鼠巨噬細胞株產生發炎之離體模式探討..........17
鹿角菜膠誘發大鼠腳掌發炎之活體模式探討..........19
研究構想..........21
材料與方法..........22
研究對象..........22
第一部分:DEE、DEH、DHE、DHH粗萃物的準備..........24
第二部分:PD1、PD2、PD3粗萃物的準備..........24
離體細胞培養模式..........24
離體細胞毒殺測試..........25
離體抗發炎活性測試..........26
小鼠巨噬細胞之存活率試驗..........27
西方點墨法分析粗萃物之抗發炎活性..........27
鹿角菜膠誘發大鼠腳掌發炎之活體模式探討..........29
抗發炎活性評估之動物實驗分組設計與流程..........30
利用動物疼痛行為改變模式分析鹿角菜膠引起大鼠腳掌發炎後之抗發炎活性..........30
溫度感異常測試(thermal hyperalgesia test)..........31
機械性觸痛反應測試(mechanical allodynia test)..........31
組織病理切片染色分析..........32
西方點墨法分析鹿角菜膠誘發大鼠腳掌發炎後之抗發炎活性..........33
斑馬魚類帕金森氏症模式..........34
離體神經保護測試..........35
斑馬魚促骨質形成測試..........35
活體斑馬魚美白活性分析..........36
PD1的安全性評估..........37
統計..........37
結果..........39
討論..........48
結論..........53
參考文獻..........93
著作...........112

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