LCModel是開發於Linux系統上，廣泛用於磁振頻譜分析的一套軟體，而其圖型介面LCMgui僅能在Linux系統上使用，並可以將不同廠商的磁振頻譜檔案轉換為LCModel可以分析的檔案格式。此份論文第一個部份為延續之前網頁介面磁振頻譜分析工具，此一工具之前僅支援GE的磁振頻譜、磁振頻譜影像與相位陣列線圈影像，我們利用LCModel支援的檔案轉換與分析，新增對Siemens與Philips兩家廠商磁振頻譜與磁振頻譜影像的分析。

我們還針對LCModel代謝物絕對定量濃度作T2校正，在相同的回訊時間(TE)下，由於各代謝物T2的不同，收到的訊號衰減程度也不同，利用補正係數校正各代謝物不同的衰減程度，使絕對定量的濃度更加精確，我們將此校正方法分別對TE=35與TE=272兩種不同TE的濃度數據實作並做比較，並比較其校正的程度與精確度。

LCModel, which is performed on Linux, has been widely used for quantitative analysis of MRS. Its interface, LCMgui, converts MRS data of various formats to RAW file for LCModel analysis automatically. In this work, we had a web-based MRS analysis tool for GE MRS, GE MRS with Phase-Array and GE 2D-MRSI and improve the capability of web-based MRS analysis tool for GE 3D-MRSI, Siemens MRS/MRSI, and Philips MRS/MRSI.

Meanwhile, T2 correction has been involved in the absolute quantification with LCModel. With the same echo-time, the different T2 value of each metabolite results in different degree of signal decay. In order to correct and make absolute concentrations more accurate, we exploit a factor to correct effect of different T2. Two groups of MRS data (TE = 35 and 272 ms) have been studied for comparison.

Figure 6
Table 7
Table 7
Chapter 1 Introduction 8
1.1 Background 8
1.2 Related Work 10
1.3 Motivation 16
Chapter 2 Material and Method 18
2.1 LCModel 18
2.1.1 Three Basic Inputs: BASIS, RAW, and Control 18
2.1.2 Three Outputs: Coord, Ps, and Table 20
2.2 Web-tool 22
2.2.1 Web Interface 22
2.2.2 Data Processing 23
2.2.3 LCModel Analysis 31
2.3 T2-Correction 33
2.3.1 Theory of Relaxation-time Correction 33
2.3.2 T2-Correction in LCModel 34
2.3.3 Design of experiment 35
Chapter 3 Result 39
3.1 Web Interface 39
3.2 Analysis Result with web-tool 42
3.3 Support files of web-tool 47
3.4 The result of T2 Correction 47
Chapter 4 Discussion and Conclusion 51
References 53

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