失眠是一種非常常見的主訴，它是一種在睡眠量不適當或睡眠品質不佳的經驗。在我們的社區中，目前失眠的盛行率約由15%到28%不等。在失眠的治療中，以藥物治療較其他治療，如：心理治療、催眠治療等等方法，來得快速且有效些。而藥物治療中，有以苯二氮平及非苯二氮平藥物（如：Zolpidem）為非常常用的安眠藥處方用藥，因為它們被證實具有療效、安全、副作用小。
本研究係為病歷回顧分析法，分析精神科門診3,152名病患的資料，主要是回顧藥物副作用，特別是有關夢遊與前行性失憶症。去比較此種副作用在台灣族群是否也是少數個案發生？
在使用長效型或中長效型BZD安眠藥門診病患406名中，有出現有前行性失憶或夢遊副作用，佔使用者的0.25%（406名中，只有1人有出現此副作用）。然而，有5.1%使用Zolpidem安眠藥門診病患出現此副作用（使用者255人中，有13人有出現此副作用）。這個研究資料可提供臨床醫師，在使用Zolpidem時出現一些類睡症副作用時，給予病患及其配偶做為使用藥物衛生教育的參考。

Insomnia, the experience of poor quality or quantity of sleep, is a very common complaint. In the community estimates for the current prevalence of insomnia range from 15 to 28%. Pharmacological treatment of insomia is faster and more effective than other treatments, including psychotherapy, hypnosis, and so on. In pharmacological treatment, benzodiazepines (BZDs) and non-benzodiazepines, including zolpidem, are very common prescribing hypnotic usages because of more effectiveness and safer side-effect profiles.
Our retrospective, current observational study is a chart review of 3,152 psychiatric outpatients, attempted to review adverse effects, specifically somnambulism and antegrade amnesia after these medications, to see whether or not, this is an infrequent occurrence in Taiwan population.
Of a total 406 long-/intermitted-half-life BZD hypnotics users, 0.25% (1 of 406) reported incidence of somnambulism and anterograde amnesia. However, 5.1% (13 of 255) reported incidence of zolpidem-induced somnambulism and anterograde amnesia. It serves as a reminder for clinicians to inquire of spouses (bed parters) of the patients about any unusual behavior of parasomnia activities when prescribing zolpidem, specifically in Taiwan population.

論文審定書 ……………………………………………………… 2
目錄 …………………………………………………………… 3-4
序與致謝 ………………………………………………………… 5
中文摘要 ……………………………………………………… 6
英文摘要 ……………………………………………………… 7
前言 …………………………………………………………… 8-22
材料與方法 ……………………………………………………… 23-26
結果 ………………………………………………………………27-31
討論 ……………………………………………………………… 32-46
圖表 ……………………………………………………………… 47-59
參考文獻 ………………………………………………………… 60-69

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