本論文主要的目標在利用各種色層分析方式分離傘形 (Xenia florida) 、叢羽 (Cespitularia sp.) 和星型 (Asterospicularia laurae) 這三種台灣產軟珊瑚以及濱海藥用植物菲律賓五味子 (Kadsura philippinensis) 之乙酸乙酯萃取物並分析鑑定所含的化學組成成分，共計分離得四十三個天然物，其中有二十五個為新化合物，並檢測分離到化合物的生物活性。

在研究期間從傘型軟珊瑚中分離出一個新骨架化合物 xeniolactone A (1) 與兩個xeniolide-type新天然物 xeniolactone B 與 C (2, 3) 及八個已知化合物florlide C、9-deoxyxeniolide B、xeniolide H、florlide A 與 G 、 floridicin 、blumiolide B 及 xeniaoxolane 。由叢羽軟珊瑚中分離出八個新化合物包括四個cespitularane 類化合物 4

This dissertation mainly discussed the investigation of three different Formosan soft corals, Xenia florida, Cespitularia sp., and Asterospicularia laurae, and also the coral medicinal herb Kadsura philippinensis. Their EtOAc extracts were investigated by chromatography. Forty-three natural products, including twenty- five new natural products were isolated and parts of their biological activities were studied.

Xeniolactone A (1), a new skeleton natural product, and xeniolactones B and C (2, 3) were isolated from Xenia florida, together with eight known compounds florlide C, 9-deoxyxeniolide B, xeniolide H, florlides A and G, floridicin, blumiolide B and xeniaoxolane . In the research of soft coral Cespitularia sp.,eighe new compounds inculding four cespitularane-type diterpenes (4

中文摘要 1
英文摘要 3

第一章、台灣產軟珊瑚之天然物研究

壹、序論
一、前言 7
二、相關化合物之研究回顧 9第一節 Xenia屬 9
第二節 Cespitularia屬 29
第三節 Asterospicularia屬 36
三、研究動機與目的 37
四、物種型態與分類地位
1. Xenia屬軟珊瑚的外觀及分類地位 38
2. Cespitularia 屬軟珊瑚的外觀及分類地位 40
3. Asterospicularia屬軟珊瑚的外觀及分類地位 41
貳、研究結果
一、 傘形軟珊瑚 Xenia florida的成分研究 42
Xeniolactone A (1) 之結構解析 42
Xeniolactone B (2) 之結構解析 51
Xeniolactone C (3) 之結構解析 57
二、 叢羽軟珊瑚Cespitularia sp. 的成分研究 64
化合物 4 之結構解析 64
化合物 5 之結構解析 72
化合物 6 之結構解析 80
化合物 7 之結構解析 88
化合物 8 之結構解析 95
化合物 9 之結構解析 102
化合物 10 之結構解析 109
化合物 11 之結構解析 117
三、 星型軟珊瑚 Asterospicularia laurae 之成份研究 124
化合物 12 之結構解析 124
化合物 13 之結構解析 136
化合物 14 之結構解析 144
化合物 15 之結構解析 152
化合物 16 之結構解析 159
化合物 17 之結構解析 168

第二章、菲律賓五味子之天然物研究

壹、序論
一、前言 177
二、相關化合物之研究回顧 180
第一節 木質酚素 181
第二節 三萜類 198
三、物種型態與分類地位 211
菲律賓五味子的外觀及分類地位 212
貳、研究結果
Kadsuphilactone A (18) 之結構解析 214
Kadsuphilactone B (19) 之結構解析 224
Taiwankadsurin A (20) 之結構解析 233
Taiwankadsurin B (21) 之結構解析 241
Taiwankadsurin C (22) 之結構解析 248
化合物23 之結構解析 255
化合物24 之結構解析 264
化合物25 之結構解析 273

第三章 結論 281

第四章 實驗程序

壹、樣品的採集及萃取分離 285
一、 Xenia florida 珊瑚之採集與分離 285
二、 Cespitularia sp. 珊瑚之採集與分離 287
三、 Asterospicularia laurae珊瑚之採集與分離 289
四、 Kadsura philippinensis菲率賓五味子之採集與分離 291
貳、實驗儀器與材料 293
参、生物活性檢測 296
第五章 文獻與附錄
壹、參考文獻 298
貳、附錄

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