Title page for etd-0607106-140016


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URN etd-0607106-140016
Author Hsiu-man Keng
Author's Email Address sharonkeng@yahoo.com.tw
Statistics This thesis had been viewed 4654 times. Download 2434 times.
Department Biological Sciences
Year 2005
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Association of Tumor Necrosis Factor a, Tumor Necrosis Factor Receptors and Interleukin-1b Genetic Polymorphisms in Palindromic Rheumatism
Date of Defense 2006-05-30
Page Count 61
Keyword
  • SNP
  • IL-1β
  • TNFRSF1B
  • TNFRSF1A
  • Palindromic rheumatism
  • TNF-α
  • Abstract ABSTRACT
    Background: Palindromic rheumatism (PR) is the rare disease that generally occurs with multiple recurring attacks of painful inflammation affecting joints and adjacent tissues. The thesis attempts to characterize the association in 10 instances of the single nucleotide polymorphisms (SNPs) of tumor necrosis factor genes (TNF-α, TNFRSF1A and TNFRSF1B), Interleukin-1β genes and Palindromic rheumatism (PR). Methods: The genetic polymorphisms of TNF-α, TNFRΙ, TNFRΠ and IL-1β genes cluster were investigated among 56 PR patients identified from the Kaohsiung Veterans General Hospital (VGHKS, Kaohsiung, Taiwan) and compared with one hundred healthy subjects. The genotypes for ten SNPs in the TNF-α, TNFRSF1A, TNFRSF1B and IL-1β genes among these 156 individuals were examined.
    Results: Experiments indicate significant count of the TNFRSF1A+36 AG genotype in PR patients (OR=4.8, 95%CI=1.8-13.0, p=0.002) and TNFRSF1A+36G allele (OR=3.94, 95%CI=1.59-9.79, p=0.003).The results also have remarkable correlation with TNFRSF1B haplotype +676/+1663 T/A (OR=2.12, CI=1.2-3.8, p=0.010). However, on significant differences were found for all the TNF-αand IL-1βpolymorphisms.
    Conclusions: Genetic polymorphisms in TNF-α receptors are associated with susceptibility and severity of the inflammatory response in the PR patients.
    Advisory Committee
  • Luo-ping Ger - chair
  • Yow-ling Shiue - co-chair
  • Ming-hong Tai - advisor
  • Files
  • etd-0607106-140016.pdf
  • indicate access worldwide
    Date of Submission 2006-06-07

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