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博碩士論文 etd-0614101-172327 詳細資訊
Title page for etd-0614101-172327
論文名稱
Title
綠島產笙珊瑚之化學成分研究
Chemical Constituents of formosan Stolnifer Tubipora musica Linnaeus
系所名稱
Department
畢業學年期
Year, semester
語文別
Language
學位類別
Degree
頁數
Number of pages
163
研究生
Author
指導教授
Advisor
召集委員
Convenor
口試委員
Advisory Committee
口試日期
Date of Exam
2001-06-09
繳交日期
Date of Submission
2001-06-14
關鍵字
Keywords
笙珊瑚
tubipora
統計
Statistics
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The thesis/dissertation has been browsed 5616 times, has been downloaded 2304 times.
中文摘要
中文摘要
綠島產笙珊瑚(Tubipora musica Linnaeus)之二氯甲烷層粗萃物,層析分離後得到九個sesquiterpenoids化合物,分別為GN32-17 (1)、 GN32-32(2)、GN32-66(3)、GN32-82(4)、GN32-83(5)、GN32-91(6)、GN32-94(7)、GN32-97(8)及GN32-98(9)。其中GN32-17(1)、GN32-32(2)、GN32-66(3)、GN32-91(6)、GN32-97(8)及GN32-98(9)為新化合物,且GN32-17(1)、GN32-66(2)及GN32-98(9)為首次在天然界中發現的新骨架,GN32-83 (5) 及GN32-94 (7) 為之前利用反應而得的化合物,而在此為第一次從天然物中發現的化合物。GN32-82(4)為已知的化合物。

Abstract
Abstract
Chromatographic separation of methylene chloride extract of Formosan stolonifer Tubipora musica Linnaeus (collected at Green Island) led to the isolation of nine sesquiterpenoids, GN32-17 (1), GN32-32 (2), GN32-66 (3), GN32-82 (4), GN32-83 (5), GN32-91 (6), GN32-94 (7), GN32-97 (8), and GN32-98 (9). Compounds 1, 2, 3, 6, 8, and 9 were new compounds . Compounds 4, 5, and 7 were known compounds. Compounds 1, 3, and 9 were new skeletons.

目次 Table of Contents
目錄
一、前言…………………………………………………1
二、Stolonifer目珊瑚之化學成分研究回顧…………………..2
三、材料之鑑定與採集………………………………………...27
四、笙珊瑚之分類地位………………………………………...27
五、化學成分之萃取與分離……………………………………28
(1) 、GN32-17(1)之分離純化………………….…..31
(2) 、GN32-32(2)之分離純化……………………...33
(3) 、GN32-66(3)之分離純化……………………...36
(4) 、GN32-82(4)之分離純化……………………...38
(5) 、GN32-83(5)之分離純化………………………41
(6) 、GN32-91(6)之分離純化………………………44
(7) 、GN32-94(7)之分離純化………………………46
(8) 、GN32-97(8)之分離純化………………………48
(9) 、GN32-98(9)之分離純化………………………51
六、結構解析
(1)、GN32-17(1)之結構解析……………………….54
(2)、GN32-32(2)之結構解析……………………….65
(3)、GN32-66(3)之結構解析………………..……...76
(4)、GN32-82(4)之結構解析…………………….…87
(5)、GN32-83(5)之結構解析……………………….98
(6)、GN32-91(6)之結構解析……………………...109
(7)、GN32-94(7)之結構解析……………………...120
(8)、GN32-97(8)之結構解析………………….…..131
(9)、GN32-98(9)之結構解析……………………...142
七、 結論………………………………………………153
八、參考文獻…………………………………………..154
九、儀器及材料………………………………………..162










圖 表 目 錄
圖次 頁次
圖一、綠島產笙珊瑚之萃取及分離流程圖………………..30
圖二、GN32-17(1)之1H-NMR圖譜…………………….57
圖三、GN32-17(1)之13C-NMR圖譜……………………58
圖四、GN32-17(1)之HSQC圖譜……………………….59
圖五、GN32-17(1)之COSY圖譜……………………….60
圖六、GN32-17(1)之HMBC圖譜……………………….61
圖七、GN32-17(1)HMBC之 correlations圖……………62
圖八、GN32-17(1)之NOESY圖譜………………………63
圖九、GN32-17(1)NOESY之 correlations圖………..…64
圖十、GN32-32(2)之1H-NMR圖譜……………………..68
圖十一、GN32-32(2)之13C-NMR圖譜…………………..69
圖十二、GN32-32(2)之HSQC圖譜………………………70
圖十三、GN32-32(2)之COSY圖譜………………………71
圖十四、GN32-32(2)HMBC之圖譜………………………72
圖十五、GN32-32(2)HMBC之 correlations圖…………..73
圖十六、GN32-32(2)之NOESY圖譜……………………..74
圖十七、GN32-32(2)之NOESY之 correlations圖………75
圖十八、GN32-66(3)之1H-NMR圖譜……………………79
圖十九、GN32-66(3)之13C-NMR圖譜…………………..80
圖二十、GN32-66(3)之HSQC圖譜……………………...81
圖二十一、GN32-66(3)之COSY圖譜……………………82
圖二十二、GN32-66(3)之HMBC圖譜……………………83
圖二十三、GN32-66(3)HMBC之 correlations圖………..84
圖二十四、GN32-66(3)之NOESY圖譜…………………..85
圖二十五、GN32-66(3)NOESY之 correlations圖………..86
圖二十六、GN32-82(4)之1H-NMR圖譜………………….90
圖二十七、GN32-82(4)之13C-NMR圖譜………………….91
圖二十八、GN32-82(4)之HSQC圖譜…………………..…92
圖二十九、GN32-82(4)之COSY圖譜……………………..93
圖三十、GN32-82(4)之HMBC圖譜……………………….94
圖三十一、GN32-82(4)HMBC之 correlations圖………...95
圖三十二、GN32-82(4)之NOESY圖譜………………..…96
圖三十三、GN32-82(4)NOESY之 correlations圖……….97
圖三十四、GN32-83(5)之1H-NMR圖譜……………..…101
圖三十五、GN32-83(5)之13C-NMR圖譜……………….102
圖三十六、GN32-83(5)之HSQC圖譜…………………..103
圖三十七、GN32-83(5)之COSY圖譜…………………..104
圖三十八、GN32-83(5)之HMBC圖譜…………………..105
圖三十九、GN32-83(5)HMBC之 correlations圖……….106
圖四十、GN32-83(5)之NOESY圖譜…………………….107
圖四十一、GN32-83(5)NOESY之 correlations圖………108
圖四十二、GN32-91(6)之1H-NMR圖譜………………….112
圖四十三、GN32-91(6)之13C-NMR圖譜…………………113
圖四十四、GN32-91(6)之HSQC圖譜……………………..114
圖四十五、GN32-91(6)之COSY圖譜……………………..115
圖四十六、GN32-91(6)之HMBC圖譜…………………..116
圖四十七、GN32-91(6)HMBC之 correlations圖……….117
圖四十八、GN32-91(6)之NOESY圖譜…………………118
圖四十九、GN32-91(6)NOESY之 correlations圖……..119
圖五十、GN32-94(7)之1H-NMR圖譜………………..…123
圖五十一、GN32-94(7)之13C-NMR圖譜……………….124
圖五十二、GN32-94(7)之HSQC圖譜…………………..125
圖五十三、GN32-94(7)之COSY圖譜…………………..126
圖五十四、GN32-94(7)之HMBC圖譜…………………..127
圖五十五、GN32-94(7)HMBC之 correlations圖……….128
圖五十六、GN32-94(7)之NOESY圖譜………………….129
圖五十七、GN32-94(7)NOESY之 correlations圖………130
圖五十八、GN32-97(8)之1H-NMR圖譜………………..134
圖五十九、GN32-97(8)之13C-NMR圖譜……………….135
圖六十、GN32-97(8)之HSQC圖譜……………………..136
圖六十一、GN32-97(8)之COSY圖譜…………………..137
圖六十二、GN32-97(8)之HMBC圖譜………………….138
圖六十三、GN32-97(8)HMBC之 correlations圖………139
圖六十四、GN32-97(8)之NOESY圖譜…………………140
圖六十五、GN32-97(8)NOESY之 correlations圖………141
圖六十六、GN32-98(9)之1H-NMR圖譜…………………145
圖六十七、GN32-98(9)之13C-NMR圖譜………………..146
圖六十八、GN32-98(9)之HSQC圖譜……………………147
圖六十九、GN32-98(9)之COSY圖譜……………………148
圖七十、GN32-98(9)之HMBC圖譜……………………..149
圖七十一、GN32-98(9)HMBC之 correlations圖……….150
圖七十二、GN32-98(9)之NOESY圖譜………………….151
圖七十三、GN32-98(9)NOESY之 correlations圖……..152
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