摘要
本論文主題為配合功能性磁振造影研究針刺對於中風復健的功效及機轉，提出一套運動監測系統，針對在f MRI環境內的手部運動加以觀察記錄。在臨床研究部份假設針灸刺激對於腦部的運動系統的恢復有助益，而神經生理機轉可藉由功能性磁振造影圖譜術加以探索。同時針灸對腦部運動系統影響的個別差異，可能可以解釋為何臨床上針灸對中風的療效的個體差異性。因此擬以運動系統為主，針對中風病人作功能性磁振造影的研究，而以手腕手掌運動功能與功能腦圖譜相比對。
此運動監測系統是必須可以在磁場裡面使用的，同時因為病人的肌力量表微弱，所以對於微小的肌肉運動須十分敏感。因此必須設計一套新的量測系統來符合這樣的需求，其中包括兩部分的訊號擷取-位置與力量，透過兩個子系統，分別針對手部位置變化情形以感應手套量測，對手部施力變化則以壓力系統量測。整合此兩項資料便能與功能腦圖譜相比對，而對於手部運動與腦部功能區反應的相關性能更深入瞭解。
本監測系統在整合手部位置、力量之訊號與功能性磁振造影圖譜顯像，將可延伸成為一復健診斷機制。透過資料分析整合能夠即時觀察復健狀態，以期規劃進一步之復健計畫，達到迅速、正確、完整的復健規劃。
關鍵字：功能性磁振造影、監測系統、運動功能、力量量測

Abstract
In this dissertation, we aim to study the acupuncture effect on stroke rehabilitation. To achieve this purpose, a monitoring system for performance evaluation of motor task in functional MRI environment is developed.
The hypothesis of the clinical study is that acupuncture stimulation at motor zone of scalp acupoint could modulate the brain activation of motor system. Such modulation effect can be explored by fMRI. So we use the monitoring system can be used to observe patients with predominantly motor deficit without remarkable speech problem. Besides the fMRI findings of motor activation and clinical motor performance will be compared.
The monitoring system must be magnetic field compatible, and furthermore, it can also detect very subtle motor performance in the case of stroke during recovery. So the specific requirements of the system challenge the need. The system includes two subsystems. One collects the position signal using a data glove and the other acquires the force signal with a pneumatic system. The understanding of the correlation of the motor task and the brain activation in depth through the integration of the position and force data can therefore be greatly improved. The monitoring system will extend to be the estimation of recovery through the integration of motor task and fMRI.

Keyword: functional MRI、monitoring system、motor task、force measurement

目錄
目錄…………………………………………………………………….…I
圖索引…………………………………………………………………..III
表索引…………………………………………………………………..IX
中文摘要…………………………………..…………………………….X
英文摘要…………………………………..……………………………XI
第一章 緒論
1-1前言……………………………………………………………1
1-2研究動機與目的………………………………………………2
1-3文獻回顧………………………………………………………3
1-4研究方向………………………………………………………6
1-5論文架構………………………………………………………9
第二章 簡介
2-1 f MRI概述……………………………………………………..10
2-2腦部活化機制….………………………………………………14
2-3手部認知……………………………………………………….17
2-3-1手部姿勢簡介…………………………………………..17
2-3-2手部運動模式規劃……………………………………..20

第三章 運動監測系統
3-1概念分析……………………………………………………...25
3-1-1功能性磁振造影…………………………………………26
3-1-2位置量測系統……………………………………………31
3-1-3握力量測系統……………………………………………31
3-2系統架構……………………………………………………...33
第四章 位置量測
4-1感應手套簡介…………………………………………………36
4-1-1環境限制………………………………………………….36
4-1-2實用性考量……………………………………………….37
4-1-3運動資料分析…………………………………………….37
4-2系統架構與流程………………………………………………38
4-2-1感應手套構造與應用…………………………………….39
4-2-2感應手套元件與應用流程……………………………….42
4-2-3 PMS後端資料處理角度分析……………………………45
4-2-4 PMS後端資料處理頻率分析……………………………55
4-2-5 PMS後端資料處理系統軟體架構………………………60
4-3問題分析與探討……………………………………………….62

第五章 握力量測
5-1設計概念……………………………………………………….65
5-2系統架構與流程……………………………………………….68
5-2-1拉把模組…………………………………………………..69
5-2-2活塞模組…………………………………………………..72
5-2-3傳輸模組…………………………………………………..74
5-2-4量測模組…………………………………………………..74
5-2-5量測流程…………………………………………………..76
5-2-6FMS後端資料分析………………………………………..78
5-3問題分析與探討………………………………………………..82
第六章 實驗規劃分析與結論
6-1實驗架構………………………………………………………85
6-1-1fMRI實驗規劃……………………………………………85
6-1-2手部位置量測實驗規劃………………………………….90
6-1-3手部力量量測實驗規劃………………………………….95
6-2結果與分析………………………………………………………98
6-2-1 fMRI影像分析…………………………………………….98
6-2-2 PMS彎曲角度結果分析…………………………………105
6-2-3 PMS反應時間結果分析…………………………………110
6-2-4 FMS結果分析……………………………………………123
第七章 結論
7-1結論……………………………………………………………..125
7-2未來展望………………………………………………………..126
參考文獻………………………………………………………………127
附錄
附錄1……………………………………………………………….133
附錄2……………………………………………………………….134
附錄3……………………………………………………………….135
附錄4……………………………………………………………….135

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