開發抵達現場進行快速分析的質譜儀是當前質譜學發展的新趨勢，本研究所開發的移動式大氣壓力質譜儀系利用「由上而下(top-down)」的策略，將商用質譜儀以及質譜操作所需的各種設備縮小化，並裝載在高機動性的平台上，提供臨場化學分析的快速篩檢。比起目前其它手提式質譜儀式以「由下而上(bottom-up)」的開發策略，必需開發新的質量分析器、電子設備、電力系統等更具優勢。
本研究總共開發了三套移動式質譜儀，是目前全球僅有的移動式質譜儀。第一套系統為車載式移動質譜儀，搭配離子阱質譜儀為基礎、第二套則是電動輔助手推式移動質譜儀，搭配四極柱質譜儀、第三套具有獨力的發電系統的車載式移動質譜儀，搭載離子阱質譜儀，實現了質譜儀可直接在室外進行化學分析。
利用本研究所開發出來的移動式大氣壓力質譜儀模擬食品及毒品篩檢。研究結果顯示：標準水溶液中DEHP的偵測極限500 ng/mL、果汁中的偵測極限為2.5 μg/mL，而牛奶經過甲苯簡易萃取後偵測極限為5.0μg/mL。奶粉中的三聚氰胺檢測，係利用二次質譜法檢測，檢測偵測極限為1 μg/g是真實事件的濃度的0.002倍。本研究並利用標準的水果防腐技術製備含有常用殺菌劑-腐絕標準品進行半定量實驗，其偵測極限約為500μg/mL，並偵測市面上柳橙表面農藥滲入水果內部的分布情形。針對購自商場進口水果和本地蔬菜進行快篩，發現有80%的蔬果有過量農藥殘留，有些蔬果甚至有超過兩種以上的農藥殘留被檢測出。
本研究並針對甲基安非他命、MDMA、K它命和海洛英標準液和粉末樣品進行快速篩檢。結果顯示甲基安非他命和MDMA的偵測極限為300μg/mL、K它命和海洛英的粉末偵測結果顯示偵測極限為1μg/g。這些偵測結果顯示，本儀器對這些樣品的快篩能力均符合需求。上述每個樣品所有檢測時間均只需數十秒，顯示開發移動式大氣壓力質譜儀進行臨場快篩的概念，已經達到一定水準。

To provide a new type of mass spectrometer for in situ chemical detection/screening is a trend of development of mass spectrometry. In this study three mobile mass spectrometers (MMS) have been developed by using top-down strategy. Commercial MS and instruments such as power supply and gas supply etc. have been integrated on electro-dynamic vehicles with vibration dampening system. MMS has high performance as commercial MS comparing with portable mass spectrometers which have been developed by using bottom-up strategy.
A mobile ambient mass spectrometer (MAMS) is combined a new type of ionization source which so-call thermal desorption-electrospray ionization (TD-ESI) with the MMS. MAMS provides rapidly and in situ chemical analysis such as food safety screening and narcotic detection.
In this thesis, DEHP tainted in food, melamine in milk products and pesticide residues on/in agricultural product have been detected to simulate reality. The results showed that their LODs are 500 ng/mL, 2.5 μg/mL and 5.0μg/mL respected to DEHP in aqua, juice and milk. And, the LOD of melamine in milk powder has been estimated about 1mg/g. Then, LOD of thiabendazole on fruits surface was 500 ng/mL and the distribution by permeating into fruit has been detected. Finally, we found that there were about 80% fruits and vegetables with agricultural residues which bought from the local markets.
Furthermore, methyl amphetamine, MDMA, ketamine and heroin have been detected to stimulate narcotic detection. The LODs of MA and MDMA standard solutions were 500 ng/mL. The LODs of ketamine and heroin powders were 1μg/g. We propose that MAMS will surely increase MS ability for in situ detection.

論文審定書…………………………………………………………i
謝誌…………………………………………………………………iii
中文摘要……………………………………………………………iv
英文摘要……………………………………………………………v
第一章 緒論 …………………………………………………………1
第一節 質譜儀的發展……………………………………………1
第二節 傳統大氣壓力質譜法 ……………………………………6
第三節 現代大氣壓力質譜法……………………………………13
第四節 移動式質譜儀的發展……………………………………42
第五節 論文目標 ………………………………………………65
第二章 儀器開發………………………………………………………67
第一節 移動式質譜儀的設計開發..………………………………67
一、避振系統………………………………………68
二、氣體供應系統……………………………………73
三、第一代移動式質譜儀……………………………77
四、第二代移動式質譜儀…………………………82
五、第三代移動式質譜儀…………………………87
第二節 熱脫附游離技術的開發…………………………………93
一、熱脫附電噴灑裝置的開發……………………93
二、熱脫附電噴灑的溫度與流速效應………………103
第三章 移動式大氣壓力質譜儀於食品安全檢測上的應用………119
第一節 食品中塑化劑的半量檢測……………………………121
第二節 奶粉中三聚氰胺的半定量檢測………………………140
第三節 農產品的農藥殘留半定量檢測………………………150
第四章 移動式大氣壓質譜儀於違禁藥品檢驗上的應用…………168
第一節 違禁藥品的化學分析簡介……………………………169
第二節 毒品檢測實驗儀器與藥品……………………………175
第三節 毒品的標準水溶液及固體樣品的快速篩檢…………178
第五章 結論…………………………………………………………192
參考文獻…………………………………………………………196

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