利用兩相法製備出直鏈烷硫為單層分子保護金奈米簇團(MPCs，AuC8)，並藉由不同的加熱處理方式(固體態及溶液態)改善奈米粒子的形狀與大小，使其達到均勻化的效果，粒子大小約為5 nm。進而利用部份置換反應，將自行合成的吡啶烷硫化合物取代置換到金奈米粒子上，並藉由穿透式電子顯微鏡、紫外/可見光光譜儀、核磁共振光譜儀、紅外線光譜儀及X-ray 光電子光譜儀(XPS)等進行鑑定分析工作。證明吡啶烷硫化合物確實可鍵結於金奈米粒子上，並可溶於多
種低極性的有機溶劑中(如甲苯、正己烷、二氯甲烷、乙醚等)，為一穩定的化合物。並且透過熱重量分析(Thermal Gravimetric Analysis，TGA)與化學分析影像能譜儀(Electron Spectroscopy for Chemical Analysis System ，ESCA)計算出其octanethiol 與pyridyl-thiol(化合物2，PyC8SH)的比例分別為2.84：1，2.73：1。

The preparation and spectroscopic characterizations of size-controlled Pyridine-functionalized gold clusters formed self-assembled 2D superlattices with hexagonal packing were studied. The characterizations of pyridine-modified Au clusters using TEM, UV-vis, NMR and ESCA techniques are also reported. Pyridine-functionalized monolayer-protected Au clusters (MPCs) were prepared as illustrated in Scheme 1. The gold nanoparticles prepared by the reduction with NaBH4 have 3.2 ± 0.88 nm average core diameters established by TEM. The ~3 nm particles were used to induce size and shap evolution with heating treatment in toluene or in TOABr (tetraoctylammonium bromide). The pyridine-functionalized MPCs exhibit an identifiable plasmon resonance band at ~515 nm. The confirmation of the functionalization of pyridyl octanethiol in Au MPCs came from the downfield NMR resonances in the region of 120-150 ppm, which were established the resonances of the Py moiety.

第壹章 緒論
1-1 簡介
1-2 MPCs(monolayer protected clusters)
1-2-1 MPCs 的合成
1-2-2 影響MPCs 粒子大小的因素
1-3 MPCs 的均勻化
1-3-1 溶液態均勻化(heating treatment-Uh)
1-3-2 固體態均勻化(solid state-Us)
1-4 MPCs 的鑑定
1-4-1 紫外/可見光譜儀(UV-vis)
1-4-2 核磁共振光譜儀(NMR)
1-4-3 傅立葉紅外線光譜儀(FT-IR)
1-4-4 穿透式電子顯微鏡(TEM)
1-4-5 X-ray 光電子光譜
(X-ray photoelectron spectroscopy，XPS)
1-5 MPCs 的應用
1-6 研究目的

第貳章 實驗部分
2-1 藥品部分
2-2 儀器部分
2-3 合成部分
2-3-1 合成流程圖
2-3-2 化合物1 及2 的合成
2-3-3 HAuCl4•xH2O的合成
2-3-4 Octanethiolate-MPCs(AuC8)的合成
2-3-5 Octanethiolate-MPCs(AuC8)溶液態的均勻化(AuC8-Uh)
2-3-6 以化合物2 修飾AuC8-Uh 的合成(AuC8-Uh-Py)
2-3-7 Octanethiolate-MPCs(AuC8)固體態的均勻化(AuC8-Us)
2-3-8 以化合物2 修飾AuC8-Us的合成(AuC8-Us-Py)
2-3-9 以化合物2 修飾AuC8 的合成(AuC8-Py)
2-3-10 AuC8-Py 溶液態的均勻化(AuC8-Py-Uh)
2-3-11 AuC8-Py 固體態的均勻化(AuC8-Py-Us)

第

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