利用自由基環化反應合成石蒜科類生物鹼，以氫化三正丁烷錫與2, 2’-偶氮二異丁腈為自由基引發劑，氯化亞銅為添加劑，將溴化苯基反應成苯基自由基，再與不飽和鍵進行分子內環化反應，而得到石蒜科類生物鹼的衍生物。

Application of free radical cyclization reaction toward the synthesis of amarylldaceae alkaloids was reported. Copper(I) chloride in tri-n-butyltin hydride and azobisisobutyronitrile were used to proceed radical cyclization. Syntheses of amarylldaceae alkaloids were proceeded using the aforementioned method to give good yields.

應用自由基環化反應合成生物鹼之研究………………………….1
壹、 生物鹼簡介…………………………………………….2
貳、 自由基簡介……………………………………….……7
參、 結果與討論…………………………………………...12
一、 phenanthridine alkaloids…….…………………...12
二、 Pyrrolophenanthridine alkaloids…………….……24
三、 Isoquinoline alkaloids………..………..………….31
肆、 實驗部分………………………………………………35
一、 儀器………………………………………………35
二、 試劑………………………………………………36
三、 過程………………………………………………36
四、 實驗步驟與數據…………………………………37
伍、 參考資料………………………………………………82

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