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URN etd-0710106-042830 Author Chun-Sui Lin Author's Email Address No Public. Statistics This thesis had been viewed 5205 times. Download 1316 times. Department Applied Mathematics Year 2005 Semester 2 Degree Ph.D. Type of Document Language English Title Optimal Designs for Calibrations in Multivariate

Regression ModelsDate of Defense 2006-06-28 Page Count 93 Keyword Maximin efficient design Optimal calibration design Relative potency Scalar optimal design Minimax design Multivariate calibration Location-shift parameter Bioassay C-criterion Classical estimator Equivalence theorem Locally optimal design Abstract In this dissertation we first consider a parallel linear model with correlated dual responses on a symmetric compact design region and construct locally optimal designs for estimating the location-shift parameter. These locally optimal designs are variant under linear

transformation of the design space and depend on the correlation between the dual responses in an interesting and sensitive way.

Subsequently, minimax and maximin efficient designs for estimating the location-shift parameter are derived. A comparison of the behavior of efficiencies between the minimax and maximin efficient designs relative to locally optimal designs is also provided. Both minimax or maximin efficient designs have advantage in terms of estimating efficiencies in different situations.

Thirdly, we consider a linear regression model with a

one-dimensional control variable x and an m-dimensional response variable y=(y_1,...,y_m). The components of y are correlated with a known covariance matrix. The calibration problem discussed here is based on the assumed regression model. It is of interest to obtain a suitable estimation of the corresponding x for a given target T=(T_1,...,T_m) on the expected responses. Due to the fact that there is more than one target value to be achieved in the multiresponse case, the m expected responses may meet their target values at different respective control values. Consideration includes the deviation of the expected response E(y_i) from its corresponding target value T_i for each component and the optimal value of calibration point x, say x_0,

is considered to be the one which minimizes the weighted sum of squares of such deviations within the range of x. The objective of this study is to find a locally optimal design for estimating x_0, which minimizes the mean square error of the difference between x_0 and its estimator. It shows the optimality criterion is

approximately equivalent to a c-criterion under certain conditions and explicit solutions with dual responses under linear and quadratic polynomial regressions are obtained.Advisory Committee Fu-Chuen Chang - chair

Chao-Ping Ting - co-chair

Chen-Tuo Liao - co-chair

Feng-Shun Chai - co-chair

Mei-Hui Guo - co-chair

Shao-Wei Cheng - co-chair

Wen-Jang Huang - co-chair

Mong-Na Lo Huang - advisor

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etd-0710106-042830.pdf Date of Submission 2006-07-10