RNA editing 為RNA轉錄後修飾的基因調控方法之一，不同於一般RNA後轉錄修飾，RNA editing主要為核苷酸置換、插入或刪除，RNA editing 依其機制可分為插入與刪除、脫胺作用2種，其中脫胺分為A-to-I和C-to-U兩種，在哺乳動物中RNA editing的形式主要為A-to-I editing，Adenosine Deaminase, RNA-Specific (ADAR)為主要的RNA A-to-I editing的催化酵素。RNA editing 在生物體中的生理意義尚不明確，同時RNA A-to-I editing在癌症中所扮演的角色至今能仍不清楚，先前的研究已顯示部分的癌症以被證實有過度RNA editing，同時RNA editing也在癌症發展中扮演特定的角色。從頭頸癌的資料顯示ADAR的表現證實在頭頸癌中有RNA over editing的現象，我們結合The Cancer Genome Atlas (TCGA)與Rigorously Annotated Database of A-to-I RNA editing (RADAR)資料庫分析在頭頸癌表現的相關基因與RNA editing的關聯性，我們依據表現量篩選出20個基因，包含10個潛在的致癌和10個潛在的抑癌基因，並利用相關文獻來探討RNA editing在頭頸癌中相關基因造成的影響，從而釐清RNA editing在癌症中可能扮演的角色。

RNA editing is one of post-transcriptional modification in gene regulation. Unlike common forms of RNA processing, RNA editing includes nucleobase modifications、
insertion or deletion. RNA editing can be classified in two form depending on mechanism, insertion or deletion and deamination. There are two kinds of deamination,A-to-I and C-to-U. A-to-I editing is the main form of RNA editing in mammals. Adenosine Deaminase, RNA-Specific (ADAR) is the main enzymes in A-to-I editing. The physiological functions of RNA editing is still unclear today. Meanwhile, the role of RNA A-to-I editing in cancer is also unclear now. Previous studies have shown that RNA is over-editing and plays a specific role in some kinds of tumor. The high expression of ADAR confirmed that RNA is over-editing in head and neck cancer. We combine The Cancer Genome Atlas (TCGA) and Rigorously Annotated Database of A-to-I RNA editing (RADAR) database to analyze the relationship between RNA editing and head and neck associated genes. We screened 20 genes which is RNA edited according to their expression level, including 10 potential oncogenes and 10 potential tumor suppressor genes where their possible function of RNA editing in head and neck cancer are discussed to clarify the role of RNA editing in cancer.

論文審定書 i
中文摘要 ii
英文摘要 iii
1前言 1
2材料與方法 10
3結果與討論 15
4 RNA editing於癌症的影響討論 27
5圖與表 30
6參考附圖 40
7參考文獻 42

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