Title page for etd-0711105-161914


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URN etd-0711105-161914
Author Chia-Chang Wang
Author's Email Address No Public.
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Department Computer Science and Engineering
Year 2004
Semester 2
Degree Master
Type of Document
Language English
Title Protein Structure Prediction Based on the Sliced Lattice Model
Date of Defense 2005-06-29
Page Count 100
Keyword
  • Sliced lattice
  • Protein structure
  • Folding
  • Ant colony system
  • Prediction
  • Abstract Functional expression of a protein in life form is decided by its tertiary structure. In the past few decades, a significant number of studies have been made on this subject. However, the folding rules of a protein still stay unsolved. The challenge is to predict the three-dimensional tertiary structure of a protein from its primary amino acid sequence. We propose a hybrid method combining homology model and the folding approach to predict protein three-dimensional structure from amino acid sequence. The previous researches on folding problem mostly take the HP (Hydrophobic-Polar) model, which is not able to simulate the native structure of proteins. We use a more exquisite model, the sliced lattice model, to approximate the native forms. Another essential factor influencing protein structures is disulfide bonds, which are ignored in the HP model. We use the ant colony optimization algorithm to approximate the folding problem with the constrained disulfide bond on the sliced lattice HP model. We show that the prediction results are better than previous methods by the measurement of RMSD(Root Mean Square Deviation).
    Advisory Committee
  • Wu-Chih Hu - chair
  • Chia-Ning Yang - co-chair
  • Yue-Li Wang - co-chair
  • Yow-Ling Shiue - co-chair
  • Chang-Biau Yang - advisor
  • Files
  • etd-0711105-161914.pdf
  • indicate in-campus access immediately and off_campus access in a year
    Date of Submission 2005-07-11

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