本論文以有限元素法探討血管支架在血管與斑的效應下，於支架植入時之變形過程。利用豬心臟之冠狀動脈與主動脈進行拉力試驗，以獲得血管材料應力擴張率曲線。本文使用之有限元素分析軟體為ABAQUS套裝軟體，血管與斑之材料模式假設為非線性彈性的Ogden模式，血管支架為彈塑性材料，氣球則為線彈性材料。
本文提出皺折狀之氣球模型模擬實際氣球膨脹過程，經過討論血管與斑之材料模式，採用合適的模式以模擬支架膨脹過程，而此模式考慮血管壁上的斑受支架膨脹擠壓破裂情形。接著探討斑的厚度與血管材料模式對於支架膨脹過程之影響。
再以Palmaz支架為基準，改變其幾何參數進行分析，討論各參數對於支架變形與應力之影響。另外分析Chen型支架之擴張能力及軸向縮短率，結果顯示Chen型支架並不適用於冠狀動脈支架，經調整其尺寸與幾何配置，擴張能力提高許多，並可用於頸動脈支架。而且Chen型支架之軸向縮短率無法達到原本預期的零縮短率。本文以Chen型支架為基準，經部分修改而提出Chen Modified型支架，可改善其軸向縮短率。

The plastic deformation of stent during the implantation process, with considering the effect of artery and plaque, was investigated in this thesis. The stress-stretch relationships of porcine coronary arteries and aortas were obtained by the tensile test. The nonlinear ABAQUS finite element software was used in the analysis. The nonlinear-elastic, plastic and linear elastic material models for artery-plaque, stent and balloon were employed respectively.
In this thesis, the initial folded balloon model was proposed to simulate the whole inflation and deflation process of balloon deformation. To investigate the effect of artery with plaque on the deformation of stent, the FEM model with considering the artery and plaque was proposed to simulate the expansion process of stents. The plaque’s destruction during the expansion of stent was studied. The effects of plaque’s thickness and the artery models on the expansion of stent were investigated.
The effects of geometrical parameters and the influences on the deformation and the stress distribution of Palmaz type stent were discussed. The expansion ability and foreshortening of Chen and Tsai’s stent were also assessed in this work. The results indicate that the limited expansion ability make Chen and Tsai’s stent be not suitable for using as coronary stent. It might be used as the stent of carotid artery if its expansion ability improved by properly designing stent’s diameter and geometry shape. The results reveal the foreshortening of Chen and Tsai’s stent does not approach to zero as mentioned by Chen. A Chen modified and Tsai’s stent was also proposed in this study. The simulation results show that the foreshortening in the Chen modified type is improved.

目錄
圖目錄
表目錄
符號說明
摘要
Abstract
第一章 緒論1
1-1 前言1
1-1-1 藥物治療2
1-1-2 冠狀動脈繞道手術2
1-1-3 心導管氣球擴張術3
1-1-4 血管支架置入術4
1-2文獻回顧6
1-3研究動機與目標10
1-4組織與章節11
第二章 血管材料模式之建立18
2-1 實驗方法及設備18
2-2 實驗步驟19
2-3 實驗結果22
2-4 Ogden材料模型擬合曲線26
第三章 有限元素模型建構 43
3-1 ABAQUS有限元素套裝軟體簡介43
3-2 有限元素分析流程44
3-3 有限元素模型45
3-3-1 模型45
3-3-2 材料性質48
3-3-3 邊界條件48
3-3-4 接觸條件49
3-3-5 負載條件49
3-4 評估項目定義50
第四章 結果與討論 67
4-1血管壁及斑對血管支架變形及應力分佈之影響67
4-2血管材料模式對模擬分析結果之影響72
4-3 Palmaz血管支架參數設計73
4-3-1支架厚度之影響74
4-3-2 溝槽角度之影響75
4-3-3 溝槽長度之影響76
4-3-4 支架材料之影響77
4-4 Chen/15-45血管支架之模擬與分析78
4-5 頸動脈血管支架之模擬與分析79
4-5-1 Chen/40-45血管支架79
4-5-2 Chen/40-20、Palmaz/40-95、Modify/40-20支架81
第五章 結論134
5-1 結論134
5-2 未來展望136
參考文獻137

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