Responsive image
博碩士論文 etd-0713105-152756 詳細資訊
Title page for etd-0713105-152756
論文名稱
Title
血管收縮素轉化
Polymorphism of angiotensin-converting enzyme gene and BMI differences between aborigines and non-aborigines
系所名稱
Department
畢業學年期
Year, semester
語文別
Language
學位類別
Degree
頁數
Number of pages
61
研究生
Author
指導教授
Advisor
召集委員
Convenor
口試委員
Advisory Committee
口試日期
Date of Exam
2005-06-23
繳交日期
Date of Submission
2005-07-13
關鍵字
Keywords
血管收縮素轉化、漢族、肥胖、台灣南部原住民
aborigines, Polymorphism of angiotensin-converting enzyme gene, BMI, ACE gene
統計
Statistics
本論文已被瀏覽 5647 次,被下載 0
The thesis/dissertation has been browsed 5647 times, has been downloaded 0 times.
中文摘要
血管收縮素轉化
Abstract
The renin–angiotensin system (RAS) plays a role in the pathogenesis of obesity. Angiotensin-converting enzyme (ACE), the component of the RAS system, has recently been found to be completely expressed in human adipose tissue. Angiotensin II, the active component of RAS, may affect adipogenesis and adipocyte metabolism. Among ACE polymorphism, the gene DD genotype has shown to be regulated with a higher agiotensin- converting enzyme level in plasma. Hence, the purpose of this research is to investigate the correlation of ACE gene polymorphism to body mass index (BMI) between aborigines and Han non-aborigines. The relationship of race and ACE insertion (I)/ deletion (D) polymorphism was also analyzed.The results showed a higher value of ACE DD genotype appeared in aborigines (35.7 %) than that in Han population (10.8 %)(p < 0.0001). BMI in aborigines was 26.4±4.6 kg/m2, while in Han population was 24.4±3.6 kg/m2 (P<0.0001). A higher waist circumference value was also found among females aborigines than that found among female in Han population (86.9±10.7 vs 84.3±9.7 cm, P<0.0001).
Simple and multiple linear regression analyses showed that both race and ACE gene polymorphism are closely correlated to BMI in all subjects. By discussion on the cases for the Han and aborigines population separately, it was found that the ACE gene polymorphism is associated with BMI in Han population it is not significant in aborigines. In aborigines, life style in culture is associated with BMI.
In conclusion, ACE gene polymorphism and race were independent factors correlated to BMI, but differences could be found between race and ACE gene polymorphism.
目次 Table of Contents
中文摘要 I
英文摘要 III
目錄 Ⅴ
第一章 緒論 1
第一節 肥胖的流行病學探討 1
第二節 肥胖形成的原因及對身體健康的影響 3
第三節 血管收縮素轉化
參考文獻 References
杜鴻賓(2002),台灣南部原住民族群AGT和ACE(I/D)基因多型性與高血壓相關研究,高雄醫學大學碩士論文
張美玲 (2002),信義鄉鄉民肥胖症之共病症及PPARγ2基因型的探討,中國醫藥學院碩士論文
葉志嶸 (2003),以多層次分析模式探討家庭層次及個人層次因素對肥胖指標之影響,台灣大學博士論文
葛應欽、謝淑芬 (1994),原住民重要死因分析,高雄醫學科學雜誌第十卷第七期﹕352-366
樊台聖、李一靜 (2001),台灣地區原住民生活型態與健康問題調查,屏東科技大學學報第十卷第二期﹕159-171,
Barton M., Carmona R., Ortmann J., Krieger J.E., Traupe T. (2004)Obesity-associated activation of angiotensin and endothelin in the cardiovascular system. The International of Biochemistry and Cell Biology. 35﹕826-837
Boutin P. (2001) Genetics of human obesity. Best Practice and Research Clinical Endocrinology and Metabolism. 15﹕391-404
Brewster U.C., Perazella M.A. (2004) The rennin-angiotensin-aldosterone system and the kidney: Effects on kidney disease. The American Journal of Medicine. 116﹕263-272
Broussard B.A., Sugarman J.R., Bachman-Carter K., (1995) Toward comprehensive obesity prevention programs in Native American ommunities. Obesity Reserch. 3﹕2895-2975
Cassis L.A., English V.L., Bharadwaj K., Boustany C.M. (2004) Differential effects of local versus systemic angiotensin II in the regulation of leptin release from adipocytes. Endocrinology. 145﹕169–174
Crisan D., Carr J. (2000) Angiotensin I-converting enzyme: Genotype and disease associations. Journal of Molecular Diagnostics. 2﹕105-115
Darimont C., Vassaux G., Ailhaud G., Negrel R. (1994) Differentiation of preadipose cells﹕paracrine role of prostacyclin upon simulation of adipose cells by Angiotensin-II. Endocrinology. 135﹕2030-2036
Engeli et al., Negrel R., Sharma A.M. (2000) Physiology and patho- physiology of adipose tissue Renin-Angiotensin system. Hypertension, 35 ﹕1270-1277
Friendrich M.J. (2002) Epidemic of obesity expands its spread to developing countries. Journal of American Medical Association. 287﹕1384-1385
Garrett R.H., Grisham C.M (2005) Metabolic integration and organ specialization. Biochemistry 3rd, Brooks/Cole,a division of Thomson learning,Inc.Chapter 27﹕879-896.
He J., Klag M.J., Appel L.J., Charleston J., Whelton P.K. (1999) The rennin-angiotensin system and blood pressure﹕difference between Blacks and Whites. American Journal of Hypertension. 12﹕555-562
Jacobsen P., Rossing K., Rossing P., Tarnow L., Mallet C., Poirier O.,
(1998) Angiotensin converting enzyme gene polymorphism and ACE inhibition in diabetic nephropathy. Kidney International. 53﹕1002-1006
Jones B.H., Standridge M.K., Moustaid N. (1997) Angiotensin II increase lipogenesis in 3T3-L1 and human adipose cells. Endocrinology. 138﹕1512-1519
Kim S., Whelan J., Claycombe K., Reath D.B., Moustaid-Moussa N.
(2002) Angiotensin II increases leptin secretion by 3T3-L1 and human adipocytes via a prostaglandin-independent mechanism. Journal of
Nutrition. 132﹕1135–1140
Kopolman P.G. (2000) Obesity as a medical problem. Nature. 406﹕635-643
Lakka H.M. (2001) Abdominal obesity is associated with increased risk of acute coronary events in men. European Heart Journal. 23﹕706–713
Lavoie J.L., Sigmund D. (2003) Minireview﹕Overview of the renin- angiotensin system---an endocrine and paracrine sysyem. Endocrinology. 144﹕2179-2183
Lin Y.C., Yen L.L., Chen S.Y.,Kao M.D., Tzeng M.S., Huang P.C. (2003) Prevalence of overweight and obesity and its associated factors: findings from National Nutrition and Health Surveyin Taiwan, 1993-1996. Preventive Medicine. 37﹕233-241
Lee Y.J., Tsai C.R. (2002) ACE gene insertion/deletion polymorphism associated with 1998 World Health Organization definition of metabolic syndrome in Chinese type 2 diabetic patients. Diabetes Care. 25﹕1002-1008
Mannan N., Boucher B.J., Evans S.J.W. (2000) Increased waist size and weight in relation to consumption of Areca catechu (betel-nut); a risk factor for increased glycaemia in Asians in East London British Journal of Nutrition. 83﹕267-275
Marx J. (2003) Cellular warriors at the battle of the bulge. Science. 299﹕846-849
O’Brien P.E., Dixon J.B. (2002) The extent of the problem of obesity. The American Journal of Surgery. 184﹕ 4S–8S (2002)
Ogden C.L., Fryar C.D., Carroll M.D., Flegal K.M. (2004) Mean body weight,height,and body mean index.United States 1960-2002.Vital and Health Statistics 347, U.S. Department of Health and Human Services Centers for Disease and Prevention
Ozata M., Ozdemir I.C., Licinio J. (1999) Human leptin deficiency caused
by a missense mutation: Multiple endocrine defects, decreased sympathetic
tone, and immune system dysfunction indicate new targets for leptin action,greater central than peripheral resistance to the effects of leptin, and
spontaneous correction of leptin-mediated defects. Journal of Clinical Endocrinology Metabolism. 84﹕3686-3695
Pasquale P.D., Cannizzaro S., Paterna S. (2004) Dose angiotensin- converting enzyme gene polymorphism affect blood pressure? Findings after 6 years of follow-up in healthy subjects. The European Journal of Heart Failure. 6﹕11-16
Polednak A.P. (2003) Trends in incidence rates for obesity-associated cancers in the US. Cancer Detection and Prevention. 27 ﹕415–421
Popkin B.M., Horton S.H., Kim S. (2001) The nutrition transition and prevention of diet-related diseases in Asia and the Pacific. Food and Nutrition Bulletin. 22﹕1-58
Rajala M.W., Scherer P.E. (2003) The adipocyte: at the crossroads of energy homeostasis, inflammation and atherosclerosis. Endocrinology. 144﹕3765-3773
Riera-Fortuny C., Real J.T., Chaves F.J., Morales-Su
電子全文 Fulltext
本電子全文僅授權使用者為學術研究之目的,進行個人非營利性質之檢索、閱讀、列印。請遵守中華民國著作權法之相關規定,切勿任意重製、散佈、改作、轉貼、播送,以免觸法。
論文使用權限 Thesis access permission:校內校外均不公開 not available
開放時間 Available:
校內 Campus:永不公開 not available
校外 Off-campus:永不公開 not available

您的 IP(校外) 位址是 3.230.162.238
論文開放下載的時間是 校外不公開

Your IP address is 3.230.162.238
This thesis will be available to you on Indicate off-campus access is not available.

紙本論文 Printed copies
紙本論文的公開資訊在102學年度以後相對較為完整。如果需要查詢101學年度以前的紙本論文公開資訊,請聯繫圖資處紙本論文服務櫃台。如有不便之處敬請見諒。
開放時間 available 已公開 available

QR Code