近年來，電腦斷層掃瞄技術的進步，掃瞄速度加快、解析度提高，使得電腦斷層圖成為臨床診斷上非常重要的工具。除了型態構造上的詳細資訊外，功能性的CT分析，更進一步提供了生理上的資訊，如血流分佈，可輔助醫師進行臨床上的診斷，提高診斷正確率。
本論文利用顯影前後電腦斷層圖影像來評估肺葉血流分佈。注射顯影劑後，因顯影劑隨血液流動，透過其顯影的效能，造成電腦斷層圖影像上CT值的變化。因此，藉由顯影前後影像的CT差值，來量化肺葉血流量的分佈，並用彩色圖的方式加以顯示，使讀圖者更容易看出血流分佈情形。
藉由肺葉血流分佈的彩色圖，可推測肺葉血流量的分佈；更進一步的，本論文以肺栓塞為例子，說明彩色圖可用來診斷肺栓塞的發生及其影響的範圍，並可做為療程的監控等。

In recent years, computer tomography (CT) has become an increasingly important tool in the clinical diagnosis, mainly because of the advent of fast scanning techniques and high spatial resolution of the vision hardware. In addition to the detailed information of morphology, functional CT also gives the physiologic information, such as perfusion. It can help doctors to make better decision.
Our goal in this paper is to evaluate lung perfusion by comparing pre and post contrast-enhanced CT images. After the contrast agent is injected, it flows with blood stream and causes the temporal changes in CT values. Therefore, we can quantize perfusion values from the changes of CT values between pre and post contrast-enhanced CT images. Then guided by color -coded maps, a quantitative analysis for the assessment of lung perfusion can be performed. As a result, it is easier for observer to determinate the lung perfusion distribution.
Moreover, we can use color - coded images to visualize pulmonary embolism and monitor therapeutic efficacy.

論文目錄……………………………………………………..I
圖表目錄……………………………………………………IV
摘要（中文）……………………………………………….X
摘要（英文）……………………………………………….XI

第一章 緒論………………………………………………..1
1.1 前言....................................................................................1
1.2 研究動機與背景…………………………………………2
1.3 論文架構…………………………………………………9
第二章 資料擷取與初步分析……………………………10
2.1 多切層電腦斷層掃描儀（MultiSlice CT）……………10
2.2 動態CT圖擷取流程……………………………………11
2.3 資料初步分析…………………………………………...12
2.3.1 動脈分析………………………………………………...12
2.3.2 肺葉分析………………………………………………...14
2.3.3 資料評估………………………………………………...14
第三章 肺栓塞偵測演算法………………………………16
3.1 演算法概述……………………………………………...16
3.2 肺葉區塊的分割與對齊………………………………...16
3.2.1 肺葉區塊的分割………………………………………...16
3.2.2 肺葉區塊的對齊………………………………………...21
3.3 肺葉資料的前處理與肺葉區塊的相減動作…………...23
3.4 相減後影像的後處理…………………………………...25
3.5 Color-mapping…………………………………………...28
3.5.1 線性的color-mapping…………………………………..28
3.5.2 分區段color-mapping…………………………………..30
3.5.2.1 三區段color-mapping…………………………33
3.5.2.2 二區段color-mapping…………………………34
3.5.3 門檻值Rc………………………………………………..36
3.6 演算法流程……………………………………………...39
第四章 結果與驗證………………………………………40
4.1 偵測結果………………………………………………...40
4.2 核子醫學影像…………………………………………...65
4.2.1 核子醫學造影簡介……………………………………...65
4.2.2 核醫造影在肺部顯像的應用…………………………...66
4.3 核子醫學資料驗證……………………………………...68
4.3.1 血流量比對……………………………………………...68
4.3.2 氣體量比對……………………………………………...70
4.3.3 V/Q比對…………………………………………………71
4.4 療效監控………………………………………………...74
第五章 結論與未來展望…………………………………76
參考文獻……………………………………………………79

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