大氣壓力質譜法(ambient mass spectrometry)是一種能在常溫常壓下直接對固體、液體以及氣體分析物進行游離的質譜技術。RF-DART/MS(Radio Frequency-Direct Analysis in Real Time/Mass Spectrometry)是一種在大氣壓力下利用低溫(cold plasma)電漿來游離氣體分子的游離技術。此方法不須經過樣品前處理步驟，且操作簡單分析快速。本研究即是利用RF-DART/MS來直接偵測氣體樣品及液體、固體樣品中的揮發性組成。
本研究第一部份是以RF-DART/MS直接偵測氣體樣品。實驗中將大蒜和口香糖分析物經口中咀嚼，或將吸煙後，再進行呼氣試驗，皆能以RF-DART/MS得到主要化學成分的離子訊號，大蒜、口香糖切片以及香菸點燃後直接偵測的結果比較，口中呼氣之離子訊號變少了，有可能是因為分析物內之水溶性成分溶於唾液或是肺臟所造成的結果。第二部份是以RF-DART/MS即時監控液體有機合成反應。在合成過種當中，採用加熱的方式，以提高合成反應速率，並增加液體樣品的揮發性，再以RF-DART/MS游離揮發之氣相分子。利用此方法，除了能得到反應物和產物的離子訊號之外，亦可以監控不穩定的中間產物。第三部份是以RF-DART/MS直接偵測固體樣中揮發性組成。本研究中分析了藥片、火藥、茶葉以及中草藥(人參、香料、生化湯)等樣品。並利用加熱的方式提高分析物的揮發度以得到不易揮發物質的組成訊號。由於此技術不需要進行樣品前處理，因此可以應用在藥片、火藥、茶葉以及中藥材的快速鑑定。

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論文摘要...............................................................................Ⅰ
目錄.......................................................................................Ⅲ
圖目錄...................................................................................Ⅴ
表目錄...............................................................................ⅩⅠ
壹、緒論..............................................................................01
一、前言..............................................................................01
二、電漿的介紹..................................................................06
三、各式電漿質譜法的發展歷史......................................10
四、RF-DART (Radio Frequency-Direct Analysis in
Real Time)..........................................................................16
五、論文目標......................................................................19
貳、實驗..............................................................................21
一、儀器設備......................................................................21
二、實驗藥品及樣品..........................................................25
三、實驗流程......................................................................27
參、結果與討論..................................................................37
一、第一部份：以RF-DART/MS直接偵測氣體樣品......37
二、第二部份：以RF-DART/MS直接連續監控液體有機 合成反應..............................................................................43
三、第三部份：以RF-DART/MS直接偵測固體樣品中揮發性組成..............................................................................57
肆、結論..............................................................................67
伍、參考資料......................................................................68
陸、附錄..............................................................................73

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