Title page for etd-0716102-172715


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URN etd-0716102-172715
Author Wen-Ying Feng
Author's Email Address fengwenying.tw@yahoo.com.tw
Statistics This thesis had been viewed 5065 times. Download 2271 times.
Department Applied Mathematics
Year 2001
Semester 2
Degree Master
Type of Document
Language English
Title Studies on the loop II coordinate structure of long α-neurotoxins
Date of Defense 2002-05-31
Page Count 63
Keyword
  • long α-neurotoxin
  • phi
  • Trp
  • Ward's Hierarchical Method
  • LIBSVM
  • bivariate von Mises distribution
  • Ophiophagus hannah neurotoxin
  • psi
  • α-bungarotoxin
  • Abstract Six new structural parameters ψB, φB, ψC, φC, ψS, and φS are proposed to enhance the side chain actions in protein structures. Programs for calculating these new parameters based on phi and psi torsion angles vector algebra calculation method are established. A bivariate model with von Mises marginal distributions are applied to establish models of phi and psi in protein class Ophiophagus hannah neurotoxins and alpha-bungarotoxins respectively. 11 global structural parameters include phi and psi torsion angles, bond lengths of C-N, C-O, Cα -C, and N-Cα, and bond angles of C-N-Cα, Cα-C-N, Cα-C-O, N-Cα-C, and O-C-N are considered to classify long alpha-neurotoxins by Ward's cluster method and LIBSVM program package. Those global structural parameters of loop II Trp residues of alpha-neurotoxins are discussed.
    Advisory Committee
  • Shangwu (Sam) Ding - co-chair
  • L.S. Chang - co-chair
  • Rong-I Hong - co-chair
  • Grace Shwu-Rong Shieh - co-chair
  • Mei-Hui Guo - advisor
  • Files
  • etd-0716102-172715.pdf
  • indicate access worldwide
    Date of Submission 2002-07-16

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