LCModel是套被廣泛使用的磁振頻譜分析軟體，LCMgui是其在Linux系統中的圖形使用者介面，可以轉換多種磁振頻譜檔案格式到LCModel可處理的檔案格式，但GE的磁振頻譜影像必須在GE Sage/IDL的套件上才可以被LCModel所分析。因此，這份研究的第一部分是建立一個支援GE檔案格式的多平台LCModel工具，可以在使用者熟稀的操作環境下，像是Windows、Linux中處理GE的磁振頻譜影像和相位陣列線圈檔案。

在磁振頻譜的實驗中使用相位陣列線圈，可以提供較好的訊雜比，經過一些整合訊號的演算法後，可預期得到較精確的定量結果。這份研究的第二部分包含了一個整合相位陣列線圈檔案的程式，透過相位校正和權重參數的計算來合併多個接受器所收到的訊號。另外，為了說明相位陣列線圈的優點及整合程式的效能，我們設計了一個實驗，分別使用Quadrature線圈和相位陣列線圈，來進行重複性的磁振頻譜實驗，來比較兩者之間分析結果的差異。

LCModel has been widely used for MR spectroscopy analysis. LCMgui, which is the built-in user interface of LCModel, based on Linux system, provides the functionality to convert MRS data of various formats to match the format of LCModel raw file, except for GE MRSI data which can be analyzed by LCModel only with GE Sage/IDL software. Hence, the first part of this work was to develop a multi-platform tool with LCModel to support all GE data, including GE MRSI data and phased array data. With this tool, users can analyze MRS data with LCModel on their familiar environment such as Windows, and Linux.

The MR spectroscopy experiments with phased array coils provide optimized SNR which lead to more accurate absolute quantification by some sophisticate combination algorithms of phased array coils. Thus, the second part of this work was to propose an algorithm of combining data obtained from phased array coils by doing phase correction and calculation of weighting factor. In addition, the comparison of the accuracy between using quadrature coil and phased array coils with different combination algorithms was investigated in order to demonstrate the efficiency of using phased array coils and the combination program.

Chapter 1 Introduction 5
1.1 Background 5
1.2 Literature Review 7
1.3 Motivation 11
Chapter 2 Theory and Method 16
2.1 Phased Array Coils 16
2.2 Webtool 17
2.2.1 Web Interface 17
2.2.2 Data Processing 18
2.2.3 LCModel Analysis 20
2.3 The Combination of Phased Array data 21
2.4 Phased Array Data V.S. LCModel 23
Chapter 3 Result 30
3.1 Webtool Interface 30
3.2 The Analysis Result by Using Webtool 31
3.3 The Performance of Eddy Current Correction 31
3.4 SNR of Each Coil Element and Combined Data 32
3.5 Phased Array Data Quantification with LCModel 33
Chapter 4 Conclusion 44
References 45

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