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博碩士論文 etd-0720108-171516 詳細資訊
Title page for etd-0720108-171516
論文名稱
Title
生理特徵在醫療診斷問題上的應用-以血氧濃度及指紋為例
Applications of biological features for medical diagnostic problems-taking oxyhemoglobin and fingerprints as examples
系所名稱
Department
畢業學年期
Year, semester
語文別
Language
學位類別
Degree
頁數
Number of pages
117
研究生
Author
指導教授
Advisor
召集委員
Convenor
口試委員
Advisory Committee
口試日期
Date of Exam
2008-06-19
繳交日期
Date of Submission
2008-07-20
關鍵字
Keywords
精神分裂症、指紋、血氧濃度、睡眠呼吸暫止症
fingerprints, schizophrenia, obstructive sleep apnea syndrome, oxyhemoglobin saturation
統計
Statistics
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The thesis/dissertation has been browsed 5674 times, has been downloaded 1803 times.
中文摘要
人體各項生理特徵皆是十分重要的生理訊息,這些訊息不僅是醫生診斷病人各項生理病徵的來源,亦是醫師作各項專業診療判斷的基礎,本研究焦點主要針對生理特徵在醫療診斷上的應用,以血氧濃度檢測睡眠呼吸暫止症與探討指紋不對稱指標在正常與精神分裂症者間差異為研究目標。
目前國內有睡眠障礙人口劇增,在中年人口中,約有4%的男性與2%的女性有睡眠呼吸暫止症(SAS),其中又有高達85%以上為阻塞性睡眠呼吸暫止症(OSAS)。目前OSAS標準檢測方式為利用多重睡眠生理檢查儀(PSG),然而,此項設備卻無法應用於普及化的檢查,本研究與中國醫藥大學附設醫院睡眠中心合作進行血氧濃度在OSAS的研究。研究結果顯示,在常用的血氧特徵中,以ODI特徵具有較佳的檢測OSAS嚴重程度的性能,在檢測門檻為AHI30 (Apnea hypopnea index)的情況下,sensitivity為87.8%,specificity為96.6%;在其他實驗結果中顯示,身體質量指數(BMI)及頸圍(Neck circumference, NC)的增加會使得發生睡眠呼吸事件時,伴隨血氧濃度下降的機率提高,利用此一特性,針對不同BMI及NC生理特徵族群檢測,可再提高檢測性能。
精神分裂症患者被認為是胎兒時期腦部不正常發展所造成,部分研究指出皮紋的形成與腦部發展時期有重疊,且認為若此時腦部有受損的神經元遷移將會造成腦部的發展缺陷,亦可能影響皮紋形成。目前許多相關研究嘗試以指紋指標來印證上述推論,大多使用局部性特徵如TFRC、AB-TRC等方式,實驗結果卻沒有一致的結論。有鑑於此,此部分研究提出異於過去的方式,以全域特徵方式求得指紋不對稱性,以對稱指的紋路流場差異進行研究。測試資料庫含40個精神分裂症患者及51位正常人,實驗結果所示,正常與患者間確實存在統計上明顯差異性。
Abstract
The physiological signals of human are very important for the diagnosis of diseases. There are two different applications of physiological signals in this study. One is using oxyhemoglobin saturation to diagnose the obstructive sleep apnea hypopnea syndrome (OSAS); the other is to determine the association between dermatoglyphics and schizophrenia by using fingerprint asymmetry measures.
The objective of the first part is to comprehensively evaluate the capablity and reliability of the previously proposed oxyhemoglobin indices derived automatically for predicting the severity of OSAS. Patients with a diagnosis of OSAS by standard polysomnography were recruited from China Medical University Hospital Sleep Center. The result revealed that when AHI cutoff value was set to 30/h, ODI achieves 87.8% sensitivity and 96.6% specificity. Another important finding is that, for both apnea and hypopnea, probability of oxyhemoglobin desaturation increases with increases of body mass index (BMI) and neck circumference (NC).
Early detection and intervention strategies for schizophrenia are receiving increasingly more attention. Dermatoglyphic patterns have been hypothesized to be indirect measures for early abnormal developmental processes that can lead to later psychiatric disorders such as schizophrenia. However, previous results have been inconsistent in trying to establish the association between dermatoglyphics and schizophrenia. The goal of second part of this work is to try to resolve this problem by borrowing well developed techniques from the field of fingerprint matching. Fingerprint images were acquired digitally from 40 schizophrenic patients and 51 normal individuals. Based on these images, the sample means of the proposed measures consistently identified the patient group as having a higher degree of asymmetry than the control group.
目次 Table of Contents
目錄 I
表目錄 IV
圖目錄 VI
摘要 X
Abstract XI
Abbreviations XII
第一章緒論 1
1.1 引言 1
1.1.1 睡眠障礙與醫學 1
1.1.2 皮紋與精神分裂症 4
1.2 文獻回顧 5
1.2.1 血氧濃度在睡眠呼吸暫止症之應用文獻回顧 5
1.2.2 指紋在精神分裂症之應用文獻回顧 7
1.3 研究動機與目的 11
1.3.1 利用血氧濃度檢測睡眠呼吸暫止症之研究動機與目的 11
1.3.2 探討指紋不對稱指標在正常與精神分裂症者間差異之研究動機與目的 13
第二章相關研究背景 14
2.1 睡眠呼吸暫止症 14
2.1.1 睡眠呼吸暫止 14
2.1.2 睡眠檢查 16
2.1.3 血氧濃度 17
2.1.4 研究硬體設備介紹 20
2.2精神分裂症 24
2.2.1 皮紋基本特徵定義 24
2.2.2 研究硬體設備介紹 27
第三章利用血氧濃度檢測睡眠呼吸暫止症 28
3.1基礎分析 28
3.2血氧濃度特徵 29
3.2.1 ODI 29
3.2.2 時域血氧特徵 31
3.2.3 頻域血氧特徵 31
3.2.4 ODI、時域與頻域血氧特徵之比較 33
3.3進階分析 44
3.4睡眠呼吸事件血氧濃度之差異性分析 44
3.5 BMI及NC的用途 52
第四章探討指紋不對稱指標在正常與精神分裂症者間差異 55
4.1資料庫 55
4.2實驗方法流程與描述 55
4.3實驗結果 70
第五章結論 74
參考文獻 76
附錄I 艾普渥斯嗜睡度量表 (Epworth sleepiness scale, ESS) 90
附錄II LBG演算法………………………………………………………………....91
附錄III Simplex演算………………………………………………………………..93
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