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博碩士論文 etd-0725100-092249 詳細資訊
Title page for etd-0725100-092249
論文名稱
Title
脾臟切除術與血栓形成之統計分析
Statistical analysis on the effect of splenectomy-induced thrombosis
系所名稱
Department
畢業學年期
Year, semester
語文別
Language
學位類別
Degree
頁數
Number of pages
52
研究生
Author
指導教授
Advisor
召集委員
Convenor

口試委員
Advisory Committee
口試日期
Date of Exam
2000-06-02
繳交日期
Date of Submission
2000-07-25
關鍵字
Keywords
最小中位數平方法、剖面圖分析、最小平方法、脾臟切除術、血栓
splenectomy, profile analysis, least median square method, least square method, thrombosis
統計
Statistics
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The thesis/dissertation has been browsed 5780 times, has been downloaded 1240 times.
中文摘要
本研究探討脾臟切除術後, 造成血小板增多症,
其須做顯微手術時,血小板增多症對血管血栓形成之影響。
嘗試討論一些可能對血栓有顯著影響的變數(包含血小板總量、
紅血球數、一氧化氮(硝酸鹽及亞硝酸鹽)、股動脈血流的變化、
血球比容、不成熟血小板數及血小板活化因子)與血栓形成與否之間的關係。
利用一些基本統計分析方法及多變量中的剖面圖分析,
了解實驗組(經脾臟切除術),及對照組(未經脾臟切除術)中各變數數值在不同階段的增加或減少,
對血栓之影響。同時利用傳統的迴歸分析與穩健迴歸分析來挑選表現有異常的點,
試著了解這些異常的點對血栓之形成是否有所關聯。
Abstract
In this work, it is of interest to study the effects of
thrombocytosis and microvascular anastomosis to that of vascular
thrombosis. Here the splenectomy is used to the experimental
subjects to have caused thrombocytosis first and later have the
microvascular anastomsis on the divided vessel. Observations on
different variables which may be related to vascular thrombosis
are obtained during the three stages of the experiments, there
are pre-splenectomy, post-splenectomy but before vascular
division, and after the vascular anastomsis. These variables
include platelet number, RBC count, Nitric oxide(nitrite and
nitrate), femoral artery perfusion unit, hematocrit,
reticulated-platelet number, and activated-platelets(p-selectin,
CD62p). The experimental units are divided into thrombocysis
group and control group. Basic statistical analysis are performed
first to see the differences between the two groups for the above
mentioned variables, and later try to use the profile analysis in
multivariate analysis to understand the changes of these
variables in different stages as well as their possible
relationships with the cause of vascular thrombosis. Finally,
classical regression and robust regression analysis for finding
outliers are also used to see whether certain characteristics of
those outliers have something to do with vascular thrombosis.
目次 Table of Contents
摘要
1. 前言
2. 資料來源與介紹
3. 統計方法介紹
4. 結果與討論
5. 結論
參考文獻
參考文獻 References
1. Body S.C. (1996). Platelet activation and interactions with
the microvasculture. J.Cardiovasc. Pharmacol,27, s13.

2. Boxer M.A. , Brown J, Ellman L. (1978). Thromboembolic risk of
post splenectomy thrombocytosis, Arch. Surg. , 113, 808.

3. Conover W.J. (1999). Practical nonparametric statistics. 3rd.
ed. Wiley , New York.

4. Ellison C.E. & Fabri P.J. (1983). Complications of
splenectomy: etiology prevention, and management. Surg. Clin.
Nor. Am. , 63, 1313-1331.

5. Holmsen H. , Day H.J. , Stormorken H. (1969). The blood
platelet release reaction. J.Haematol, 8, 1.

6. Johnson P.C. (1990). Platelet-mediated thrombosis in
microvascular surgery: New knowledge and strategies. Plast
Reconstr. Surg., 86, 259-367.

7. Johnson W. A. & Wichern D. W. (1998). Applied multivariate
statistical Analysis, 4th. ed. Prentice-Hall.

8. Nachman R.L. & Silverstein R. (1993). Hypercoagulable states.
Ann. Intern. Med., 199(8), 819-827.

9. Neter J. & Wasserman W. (1996). Applied linear statistical
models, 3rd. ed. Homewood, Ill.

10. Rousseeuw P.J. & Leroy A.M. (1987). Robust regression and
outlier detection, Wiley , New York.

11. Traetow W.D. , Fabri P.J. , Carey L.C. (1980). Changing
indications for splenectomy, Arch. Surg. , 115, 7-451.
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