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論文名稱 Title |
脾臟切除術與血栓形成之統計分析 Statistical analysis on the effect of splenectomy-induced thrombosis |
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系所名稱 Department |
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畢業學年期 Year, semester |
語文別 Language |
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學位類別 Degree |
頁數 Number of pages |
52 |
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研究生 Author |
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指導教授 Advisor |
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召集委員 Convenor |
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口試委員 Advisory Committee |
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口試日期 Date of Exam |
2000-06-02 |
繳交日期 Date of Submission |
2000-07-25 |
關鍵字 Keywords |
最小中位數平方法、剖面圖分析、最小平方法、脾臟切除術、血栓 splenectomy, profile analysis, least median square method, least square method, thrombosis |
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統計 Statistics |
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中文摘要 |
本研究探討脾臟切除術後, 造成血小板增多症, 其須做顯微手術時,血小板增多症對血管血栓形成之影響。 嘗試討論一些可能對血栓有顯著影響的變數(包含血小板總量、 紅血球數、一氧化氮(硝酸鹽及亞硝酸鹽)、股動脈血流的變化、 血球比容、不成熟血小板數及血小板活化因子)與血栓形成與否之間的關係。 利用一些基本統計分析方法及多變量中的剖面圖分析, 了解實驗組(經脾臟切除術),及對照組(未經脾臟切除術)中各變數數值在不同階段的增加或減少, 對血栓之影響。同時利用傳統的迴歸分析與穩健迴歸分析來挑選表現有異常的點, 試著了解這些異常的點對血栓之形成是否有所關聯。 |
Abstract |
In this work, it is of interest to study the effects of thrombocytosis and microvascular anastomosis to that of vascular thrombosis. Here the splenectomy is used to the experimental subjects to have caused thrombocytosis first and later have the microvascular anastomsis on the divided vessel. Observations on different variables which may be related to vascular thrombosis are obtained during the three stages of the experiments, there are pre-splenectomy, post-splenectomy but before vascular division, and after the vascular anastomsis. These variables include platelet number, RBC count, Nitric oxide(nitrite and nitrate), femoral artery perfusion unit, hematocrit, reticulated-platelet number, and activated-platelets(p-selectin, CD62p). The experimental units are divided into thrombocysis group and control group. Basic statistical analysis are performed first to see the differences between the two groups for the above mentioned variables, and later try to use the profile analysis in multivariate analysis to understand the changes of these variables in different stages as well as their possible relationships with the cause of vascular thrombosis. Finally, classical regression and robust regression analysis for finding outliers are also used to see whether certain characteristics of those outliers have something to do with vascular thrombosis. |
目次 Table of Contents |
摘要 1. 前言 2. 資料來源與介紹 3. 統計方法介紹 4. 結果與討論 5. 結論 參考文獻 |
參考文獻 References |
1. Body S.C. (1996). Platelet activation and interactions with the microvasculture. J.Cardiovasc. Pharmacol,27, s13. 2. Boxer M.A. , Brown J, Ellman L. (1978). Thromboembolic risk of post splenectomy thrombocytosis, Arch. Surg. , 113, 808. 3. Conover W.J. (1999). Practical nonparametric statistics. 3rd. ed. Wiley , New York. 4. Ellison C.E. & Fabri P.J. (1983). Complications of splenectomy: etiology prevention, and management. Surg. Clin. Nor. Am. , 63, 1313-1331. 5. Holmsen H. , Day H.J. , Stormorken H. (1969). The blood platelet release reaction. J.Haematol, 8, 1. 6. Johnson P.C. (1990). Platelet-mediated thrombosis in microvascular surgery: New knowledge and strategies. Plast Reconstr. Surg., 86, 259-367. 7. Johnson W. A. & Wichern D. W. (1998). Applied multivariate statistical Analysis, 4th. ed. Prentice-Hall. 8. Nachman R.L. & Silverstein R. (1993). Hypercoagulable states. Ann. Intern. Med., 199(8), 819-827. 9. Neter J. & Wasserman W. (1996). Applied linear statistical models, 3rd. ed. Homewood, Ill. 10. Rousseeuw P.J. & Leroy A.M. (1987). Robust regression and outlier detection, Wiley , New York. 11. Traetow W.D. , Fabri P.J. , Carey L.C. (1980). Changing indications for splenectomy, Arch. Surg. , 115, 7-451. |
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