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URN	etd-0725100-160731
Author	Kuang-Chih Hung
Author's Email Address	media200@ms53.hinet.net
Statistics	This thesis had been viewed 4239 times. Download 495 times.
Department	Marine Resources
Year	1999
Semester	2
Degree	Master
Type of Document
Language	zh-TW.Big5 Chinese
Title	Studies on the Cytotoxic Secondary Metabolites of the Formosan Gorgonian Isis hippuris
Date of Defense	2000-07-04
Page Count	80
Keyword	hippuris isis isis hippuris isishippuric acid gorgonian suberosanone subergorgia acid suberosenone
Abstract	Abstract The n-hexane extract of Formosan gorgonian coral Isis hippuris (Isididae) collected from Green Island was found to exhibit significant cytotoxicity against P-388, A-549 and HT-29 cell lines. Cytotocicity-guided fractionation of this extract led to isolation of a known subersenone (1), five new suberosanane analogues, suberosanone (2), suberosenol A (3), suberosenol B (4), suberosenal A acetate (5) and suberosenol B acetate (6), two sesquiterpenes of novel skeletons, isishippuric acid A (7) and B (8). Three known compounds, subergorgic acid (9). 3-hexadecyl-5-hydroxy- 5-methyl-5-hydrofuran-2-one (10) and prenga-1,4-diene-3,20-dione (11) were also isolated along with the novel compound. Compounds 2-6 and 8 showed potent cytotoxicities against P-388, A-549 and HT-29 cells.
Advisory Committee	none - chair none - co-chair none - co-chair none - advisor
Files	洪廣智碩士論文.pdf indicate access worldwide
Date of Submission	2000-07-25

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