Title page for etd-0725100-160731


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URN etd-0725100-160731
Author Kuang-Chih Hung
Author's Email Address media200@ms53.hinet.net
Statistics This thesis had been viewed 4604 times. Download 589 times.
Department Marine Resources
Year 1999
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Studies on the Cytotoxic Secondary Metabolites of the Formosan Gorgonian Isis hippuris
Date of Defense 2000-07-04
Page Count 80
Keyword
  • hippuris
  • isis
  • isis hippuris
  • isishippuric acid
  • gorgonian
  • suberosanone
  • subergorgia acid
  • suberosenone
  • Abstract Abstract
    The n-hexane extract of Formosan gorgonian coral Isis hippuris (Isididae) collected from Green Island was found to exhibit significant cytotoxicity against P-388, A-549 and HT-29 cell lines. Cytotocicity-guided fractionation of this extract led to isolation of a known subersenone (1), five new suberosanane analogues, suberosanone (2), suberosenol A (3), suberosenol B (4), suberosenal A acetate (5) and suberosenol B acetate (6), two sesquiterpenes of novel skeletons, isishippuric acid A (7) and B (8). Three known compounds, subergorgic acid (9). 3-hexadecyl-5-hydroxy- 5-methyl-5-hydrofuran-2-one (10) and prenga-1,4-diene-3,20-dione (11) were also isolated along with the novel compound. Compounds 2-6 and 8 showed potent cytotoxicities against P-388, A-549 and HT-29 cells.
    Advisory Committee
  • none - chair
  • none - co-chair
  • none - co-chair
  • none - advisor
  • Files
  • 洪廣智碩士論文.pdf
  • indicate access worldwide
    Date of Submission 2000-07-25

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