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博碩士論文 etd-0725105-230130 詳細資訊
Title page for etd-0725105-230130
論文名稱
Title
α1-抗胰蛋白
Expression and characterization of C-terminus of α1-antitrypsin
系所名稱
Department
畢業學年期
Year, semester
語文別
Language
學位類別
Degree
頁數
Number of pages
66
研究生
Author
指導教授
Advisor
召集委員
Convenor
口試委員
Advisory Committee
口試日期
Date of Exam
2005-07-07
繳交日期
Date of Submission
2005-07-25
關鍵字
Keywords
α1-抗胰蛋白
α1-antitrypsin
統計
Statistics
本論文已被瀏覽 5705 次,被下載 5087
The thesis/dissertation has been browsed 5705 times, has been downloaded 5087 times.
中文摘要
α1-antitrypsin屬於serpin(serine proteinase inhibitor)蛋白家族的一員,目前發現約有40幾種蛋白屬於serpin蛋白家族,廣佈於動物、植物體內,甚至在某些病毒中也發現類似的蛋白。在人類方面,serpin蛋白主要是存在血液之中,隨時調控人體內的各種機制,如:凝血機制、補體系統,發炎反應等等都需要serpin蛋白來調控。為了研究serpin及
Abstract
α1-antitrypsin(α1-AT)is one of over 40-member family of serine protease inhibitors, regulating trypsin and elstase activities by the formation of covalently bound complex. The mechanism of which serpin and enzyme form covalent complex is not clear, but two theorise have been proposed. One is opposite pole theory (OPT) proposed by Huntington et al.(2000), suggesting that after serpin is cleaved by serine protease, the P1-linked enzyme is over-swinging about 70
目次 Table of Contents
中文摘要......................Ⅰ
英文摘要......................Ⅱ
英文縮寫表.....................Ⅲ
第一章 緒論
一. α1-antitrypsin的發現..................1
二. α1-antitrypsin的缺失..................2
三. α1-antitrypsin複合物..................4
四. α1-antitrypsin及serpin結構...............6
五. trypsin與elastase....................8
六. α1-antitrypsin的分子機制................8
七. 存在的問題及實驗目的................10
第二章 實驗材料與方法
一. 質體的改造.....................12
聚合
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