Title page for etd-0727101-153250


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URN etd-0727101-153250
Author Yi-Lea Yang
Author's Email Address No Public.
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Department Marine Resources
Year 2000
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Studies on Cytotoxic Secondary Metabolities of the Formosan
Gorgonian Sinularia gibberosa and Isis hippuris.
Date of Defense 2001-06-19
Page Count 123
Keyword
  • Sinularia gibberosa
  • Isis hippuris
  • Abstract In our continuing study on the chemical constituents of Taiwanese soft corals, the EtOAc extracts of a gorgonian coral Isis hippuris and a alcyonarian coral Sinularia gibberosa were investigated, respectively. Seven compounds, including 3α,11β-dihydroxy-24-methyl-22,25epoxy-5α- furostan-18,20β-lactone (1), 3-acetyl-2-deacetyl-22R-hippurin-1 (2), hippuristerone F (3), hippurin-1 (4), 22-epi-hippurin-1 (5), 3-acetyl-2- desacetyl-22-epi-hippurin-1 (6) and 2-desacetyl-22-epi-hippurin-1 (7) were isolated from I. hippuris. Three metabolites, 3β,11-dihydroxy-24- methylene-9,11-secocholest-5-en-9-one (8), 3β,11-dihydroxy-24-methyl-9, 11-secocholest-5-en- 9-one (9) and 3β-hydroxy-11-acetoxy-24-methylene-9, 11-secocholest-5-en-9-one (10) were isolated from S. gibberosa. Among them, compounds 1–3, are new products. All metabolites 1–10 are steroids.
      The structures of 1–10 were determined by physical and spectral analysis, including IR, MS, 1D NMR (1H, 13C) and 2D NMR ( 1H-1H COSY, HMQC, HMBC and NOESY ) and by comparison with the related physical and spectral data of the known compounds.
      The cytotoxicity of the isolates against the P-388 ( mouse lymphocytic leukemia ), A-549 ( human lung adenocarcinoma ) and HT-29 ( human colon adenocarcinoma ) cancer cell lines were studied. Compound 9 and 10 showed significant cytotoxicity against P-388 cancer cell line. Metabolites 6 and 8 showed significant cytotoxicity against P-388 and HT-29 cancer cell lines. Compound 2, 4 and 5 exhibited potent cytotoxicity against the growth of P-388, A-549 and HT-29 cancer cell lines.
    Advisory Committee
  • Y-G Wu - chair
  • J-N Lin - co-chair
  • J-H Sheu - advisor
  • Files
  • etd-0727101-153250.pdf
  • indicate accessible in a year
    Date of Submission 2001-07-27

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