本研究針對台灣墾丁國家公園海域所採集的軟珊瑚Nephthea chabrolii所含有的化學成分進行探討，並分離純化出九個化合物，其中七個為新的天然化合物，分別為chabrolosteroid A (1)、chabrolosteroid B (2)、chabrolosteroid C (3)、chabrolosteroid D (4)、chabrolosteroid E (5)、chabrolosteroid F (6)、chabrolosteroid G (7)，與兩個已知的化合物loliolide (8)、teuhetenone A (9)。化合物1–9之化學結構及相對立體構型均是以各種光譜解析(1D NMR、2D NMR、IR及MS)及文獻比對的方法加以確立。同時，並將所獲得之天然化合物進行癌細胞株的細胞毒殺活性測試。

Investigation on the chemical constituent of a Formosan soft coral Nephthea chabrolii, collected along the coast off Kenting, has led to the isolation of nine marine natural products (1–9), including seven new compounds, chabrolosteroids A–G (1–7), and two known compounds, loliolide (8) and teuhetenone A (9). The structures of 1–9 were determined on the basis of spectroscopic analyses, including MS, IR, 1D NMR, and 2D NMR. Cytotoxicities of 1–9 against selected cancer cell lines were also measured.

目錄

頁次
中文摘要 XI
英文摘要 XII
壹、緒論
一、前言 1
二、研究動機 3
三、Nephthea屬軟珊瑚過去相關研究概要 6

貳、實驗程序與方法
一、生物樣品採集時間、地點與分類地位 22
二、萃取與分離純化步驟 23
三、實驗器材與溶劑 27

陸、參考文獻

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