國立中山大學,National Sun Yat-sen University,學位論文,thesis/dissertation,多取代,Synthetic Studies Toward Polysubstituted Pyridin-2-ones and Vitamin B6 Derivatives

論文名稱 Title	多取代 Synthetic Studies Toward Polysubstituted Pyridin-2-ones and Vitamin B6 Derivatives
系所名稱 Department	化學系 Department of Chemistry
畢業學年期 Year, semester	93 學年度第 2 學期 The spring semester of Academic Year 93	語文別 Language	中文 Chinese
學位類別 Degree	碩士 Master	頁數 Number of pages	81
研究生 Author	鍾文軒 Wen-hsuan Chung
指導教授 Advisor	張彥誠 Nein-Chen Chang
召集委員 Convenor	周金興 Chin-Hsing Chou
口試委員 Advisory Committee	曾誠齊 Cherng-Chyi Tzeng
口試日期 Date of Exam	2005-06-03	繳交日期 Date of Submission	2005-08-19
關鍵字 Keywords	位置選擇性親核加成反應、、[3+3]環合加成反應、維他命B6衍生物 Vitamin B6 derivatives, [3+3] annulation, pyridine-2-one, regioselective addition reaction
統計 Statistics	本論文已被瀏覽 5697 次，被下載 1750 次 The thesis/dissertation has been browsed 5697 times, has been downloaded 1750 times.

中文摘要
利用[3+3]環合加成反應可以建構出不對稱環戊亞醯胺，經位置選擇親核加成反應後在C6位置得到衍生出官能基，再將其應用到多取代
Abstract
We can construct asymmetric glutarimide while using [3+3] annulation.Then we can build substituent group in C6 position after choosing regioselective addition reaction, and then apply it to synthetic studies toward polysubstituted pyridin-2-ones and Vitamin B6 derivatives.

目次 Table of Contents
壹、緒論....................1 貳、結果與討論..............11 參、結論與未來展望..........28 肆、實驗部分................30 伍、參考文獻................76

參考文獻 References
1. (a) Rubiralta, M.; Giralt, E.; Diez, A. Piperidine: Structure, Preparation, Reactivity, and Synthetic Applications of Piperidine and its Serivatives; Elsevier: Amsterdam, 1991; (b) Strunz, G. M.; Findlay, J. A. The Alkaloids; Academic Press: New York, 1985; Vol. 26, p 89; (c) Southon, I. W.; Buckingham, J. Dictionary of Alkaloids; Chapman and Hall: London, 1989; (d) Daly, J. W. J. Nat. Prod. 1998, 61, 162. 2. (a) Comins, D. L.; Hong, H.; Saha, J. K.; Jianhua, G. J. Org. Chem. 1994, 59, 5120; (b) Comins, D. L.; Hong, H.; Jianhua, G. Tetrahedron Lett. 1994, 35, 5331; (c) Bernstein, P. R.; Gomes, B. C.; Kosmider, B. J.; Vacek, E. P.; Williams, J. C. J. Med. Chem. 1995, 38, 212; (d) Kozikowski, A. P.; Campiani, G.; Sun, L.-Q.; Wang, S.; Saxena, A.; Doctor, B. P. J. Am. Chem. Soc. 1996, 118, 11357; (e) Williams, D. R.; Lowder, P. D.; Gu, Y.-G. Tetrahedron Lett. 1997, 38, 327. 3. Vandenberghe, S. M.; Buysens, K. J.; Meerpoel, L.; Loosen, P. K.; Toppet, S. M.; Hoornaert, G. J. J. Org. Chem.1996, 61, 304. 4. Zhang, S.; Liebeskind, L. S. J. Org. Chem. 1999, 64, 4042. 5. Hachiya, I.; Ogura, K.; Shimizu, M. Org. Lett. 2002, 4, 2755. 6. Carles, L.; Narkunan, K.; Penlou, S.; Rousset, L.; Bouchu, D.; Ciufolini, M. A. J. Org. Chem. 2002, 67, 4304. 7. Sutherland, A.; Gallagher, T. J. Org. Chem. 2002, 68, 3352. 8. Wijtmans, W.; Pratt, D. A.; Brinkhorst, J.; Serwa, R.; Valgimigli, C.; Bisagni, E. J. Med. Chem.2005, 48, 1948. 9. Nguyen, C. H.; Gullemont, J.; Benjahad, A.; Croisy, M.; Moonneret, L.; Pedulli, G. F.; Porter, N. A. J. Org. Chem.2004, 69, 9215. 10. Chang, M. Y.; Chang, B. R.; Tai, H. M.; Chang, N. C. Tetrahedron Lett. 2000, 41, 10273. 11. Tai, H. M.; Chen, B. F.; Cheng, C. C.; Chang, N. C. J. Org. Chem. 2005, 70, 1780. 12. Culbertson, S. M.; Enright, G. D.; Ingold, K. U. Org. Lett. 2003, 5, 2659.

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