利用α-磺酸基乙基胺所形成之雙陰離子與有各種不同取代基的不飽和酯化合物進行三加二環合加成反應，以它來建構含氮五員環焦谷胺酯化合物。再經由官能基的修飾來達到合成去甲基次檳榔鹼,克憂果及天芥菜烷的目的。

Carbon skeleton of polysubstituted pyroglutamates with three contiguous asymmetric centers was built up in one base-induced coupling/cyclization reaction of α-sulfonylacetamide with 2-bromo-2-propenoates and has been used as the key step in the formal synthesis of isoguvacine paroxetine, and psudoheliotridane.

目錄
第一部分 : 去甲基次檳榔鹼與克憂果的合成研究
一、前言 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥01
二、結果與討論‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥07
三、結論與未來展望‥‥‥‥‥‥‥‥‥‥‥‥‥‥16
四、實驗部分‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥17
五、參考文獻‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥37
附錄A (NMR 光譜資料)

第三部分 : 天芥菜烷的合成研究
一、前言 ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥40
二、結果與討論‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥45
三、結論與未來展望‥‥‥‥‥‥‥‥‥‥‥‥‥‥49
四、實驗部分‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥50
五、參考文獻‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥65
附錄B (NMR 光譜資料)
附錄C publication

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