本文之研究目的主要探討生醫材料機械性質之測定，利用拉力試驗機進行主動脈及冠狀動脈之擴張與拉伸試驗，基於生物軟組織不可壓縮之條件，可以獲得血管應力-拉伸率曲線。利用非線性Ogden材料模型曲線擬合實驗結果，所得出之材料常數應用於血管支架之有限元素模擬，可以成功模擬血管支架膨脹及回彈過程。
利用微米壓痕試驗量測人類牙齒琺瑯質與象牙質之機械性質，透過變化壓痕試驗參數測量楊氏模數，藉以探討參數對於量測值之影響。『最大負載』參數對於楊氏模數測量值影響很大，建議最大負載在10 ~ 100 mN範圍內，可以獲得較穩定之測量值。『卸載曲線採用比率』與『年齡』參數對於楊氏模數測量值並不敏感。
本文提出結合有限元素法及最佳化原理，以曲線擬合微米壓痕試驗加載及卸載過程之負載-壓痕深度曲線，可以成功萃取矽基底及薄膜之機械性質，包括楊氏模數、降伏強度及應變硬化指數。所萃取出之0.2 ~ 1.4 μm TiN薄膜楊氏模數均比文獻塊材數值400 GPa為低，當薄膜厚度小於0.8 μm時，楊氏模數隨著厚度減少而下降。由此可以推論薄膜厚度0.8 μm可能是使用塊材材料性質之巨觀力學之上界。

The mechanical properties of biomedical materials were determined and discussed in this study. The extension and tensile tests for aorta and coronary artery were carried out using tensile testing machine. Based on incompressibility of biological soft tissue, the stress-stretch curves of arteries were obtained. This study proposed a nonlinear Ogden material model for the numerical simulation of coronary artery extension during stent implantation. The corresponding Ogden model parameters were derived by the obtained stress-stretch curves from tensile tests. For validation, the proposed nonlinear Ogden material model for coronary artery was applied to a Palmaz type stent implantation process. The simulated stent deformation was found to be reasonable. It had a good correlation with the measured results.
The microindentation experiments were used to measure the mechanical properties of enamel and dentine of human teeth in this study. To reveal the relation between the experimental parameters and measured mechanical properties, Young’s moduli were investigated by varying experimental parameters. The parameter of maximum indentation load significantly influences measured values. Young’s modulus varies very slightly when 10 to 100 mN of maximum indentation load applied. Young’s modulus is not sensitive to the parameters of portion of unloading data and teeth age.
The combination of finite element analysis and curve-fitting method is proposed to determine the mechanical properties of thin film deposited on substrate. The mechanical properties of thin film, i.e. Young’s modulus, yield strength and strain-hardening exponent, were extracted by applying an iterative curve-fitting scheme to the experimental and simulated force-indentation depth curves during the microindentation loading and unloading processes. The variation of mechanical properties of TiN thin films with thicknesses ranging from 0.2 to 1.4 μm was extracted. The results presented the film thickness effect makes the Young’s modulus of TiN thin films reduces with reducing film thickness, particularly at thicknesses less than 0.8 μm. Therefore, it can be inferred that a film thickness of 0.8 μm possibly represents the upper bound when employing macroscopic mechanics with bulk material properties.

致謝................................................................................................................................... i
摘要.................................................................................................................................. ii
Abstract........................................................................................................................... iii
目錄.................................................................................................................................. v
表目錄............................................................................................................................ vii
圖目錄........................................................................................................................... viii
符號說明......................................................................................................................... xi
第一章 緒論................................................................................................................ 1
1-1 前言................................................................................................................ 1
1-1-1 簡介....................................................................................................... 1
1-1-2 血管機械性質之量測........................................................................... 3
1-1-3 人類牙齒機械性質之量測................................................................... 5
1-1-4 生醫材料鍍膜機械性質之測定........................................................... 5
1-2 研究動機與方法............................................................................................ 5
1-3 文獻回顧........................................................................................................ 6
1-4 組織與章節.................................................................................................. 11
第二章 血管機械性質之量測.................................................................................. 13
2-1 非線性Ogden材料模型.............................................................................. 13
2-2 血管試件拉伸試驗...................................................................................... 14
2-2-1 血管試件............................................................................................. 15
2-2-2 拉伸試驗............................................................................................. 23
2-2-3 周向應力-拉伸率曲線........................................................................ 29
2-2-4 軸向應力-拉伸率曲線........................................................................ 30
2-3 試驗結果...................................................................................................... 32
第三章 人類牙齒機械性質之量測.......................................................................... 50
3-1 微米壓痕試驗.............................................................................................. 50
3-2 壓痕試驗數據之分析理論.......................................................................... 52
3-3 微米壓痕實驗設備系統.............................................................................. 62
3-4 不鏽鋼與純銅微米壓痕實驗...................................................................... 65
3-4-1 實驗試件與實驗項目......................................................................... 65
3-4-2 實驗結果............................................................................................. 72
3-5 人類牙齒微米壓痕實驗.............................................................................. 84
3-5-1 實驗試件與實驗項目......................................................................... 84
3-5-2 實驗結果............................................................................................. 85
第四章 生醫材料鍍膜機械性質之測定................................................................ 110
4-1 薄膜微米壓痕實驗.................................................................................... 110
4-2 有限元素數值模擬.................................................................................... 110
4-2-1 有限元素模型................................................................................... 111
4-2-2 模擬分析程序................................................................................... 114
4-3 模擬分析結果............................................................................................ 117
4-3-1 萃取矽基底之機械性質................................................................... 117
4-3-2 萃取TiN薄膜之機械性質............................................................... 123
4-3-3 TiN薄膜厚度效應............................................................................ 123
第五章 結論............................................................................................................ 129
5-1 總結............................................................................................................ 129
5-2 未來展望.................................................................................................... 130
參考文獻...................................................................................................................... 131

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