Title page for etd-0901102-212114


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URN etd-0901102-212114
Author L.-F. Huang
Author's Email Address m8952613@student.nsysu.edu.tw
Statistics This thesis had been viewed 4613 times. Download 1062 times.
Department Marine Resources
Year 2001
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Futher Studies on the Steroidal Natural Productsfrom the Formosan Gorgonian Isis hippuris
Date of Defense 2001-07-22
Page Count 133
Keyword
  • steroid
  • Isis hippuris
  • coral
  • cytotoxicity
  • marine natural products
  • gorgonian
  • Abstract Abstract

    Several sesquiterpenes isolated from a Formosan gorgonian coral Isis hippuris have shown significant cytotoxic activity against various cancer cell lines. In order to search other active components, we have investigated the chemical constituent of I. hippuris from a Green Island specimen. In the cytotoxcity assay, the EtOAc extract showed potent cytotoxic response toward P-388, A549 and HT-29 cancer cell lines. Thus, the investigation on the chemical content of this extract was carried out.
    This study finally led to the isolation of twelve steroids(1-12). Nine metabolites, hippuristerone G (1)、hippuristerone H (2), hippuristerone I (3)、hippuristerone J (4)、hippuristerol E (5)、2a,3a-diacetoxy-24-methyl-
    11b,18; 18,20b; 22,25-triepoxy-5a-furostane (7)、2a,3a-diacetoxy-11b-
    hydroxy-24-methyl-22,25-epoxy-5a-furostan-18,20b-lactone (10)、3a-
    acetoxy-11b,18a-dihydroxy-24-methyl-18,20b; 22,25-diepoxy-5a-
    furostane (11) and 2a,3a-diacetoxy-11b,18a-dihydroxy-24-methyl-18,
    20b; 22,25-diepoxy-5a-furostane (12) are new compounds, whereas hippuristerone A (6), 3a-acetoxy-24-methyl-11b,18; 18,20b; 22,25-
    triepoxy-5a-furostane (7) and 3a-acetoxy-11b-hydroxy-24-methyl-22,25-
    epoxy-5a-furostan-18,20b-lactone (9) are known compounds. The structures of 1-12 were elucidated by spectroscopic evidences (IR, MS, 1D NMR, 2D NMR) and chemical method. The stereochemistries of compounds 7 and 9 were further confirmed by single-crystal X-ray diffraction analyses. Cytotoxicity test revealed that hippuristerone I (3) exhibited moderate inhibition toward NCI cancer cell line.
    Advisory Committee
  • Yang-Chang Wu - chair
  • Chung-Nan Lin - co-chair
  • Jyh-Horng Sheu - advisor
  • Files
  • etd-0901102-212114.pdf
  • indicate accessible in a year
    Date of Submission 2002-09-01

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