Annexin-7 (ANX7) 基因位在人類染色體10的長臂21的位置。此位置長久以來被假說為星狀細胞瘤 (一種腦癌)、乳癌以及其他癌症的腫瘤抑制基因 (TSG) 的位置。我們決定多種細胞株、139個包含各種惡化程度腦瘤病人和84個胃癌病人的腫瘤組織ANX7表現量，來測試ANX7是否為腫瘤抑制作用的其中一個環節的基因。細胞型態較為惡性者ANX7的表現量的比例較高 (2.14倍)。同樣的人類的ANX7蛋白質於GBM腦瘤的表現量較其他惡化程度的腦瘤少 (p = 0.04)。而腫瘤細胞中ANX7蛋白質的表現量也和胃癌的分化有顯著關係 (p=0.001)。因此ANX7在腫瘤惡化中扮演重要角色，而且ANX7的缺少表現可以作為腫瘤演變的生化指標。

The annexin-7 (ANX7) gene is located on human chromosome 10q21, a site long been hypothesized to harbor a tumor suppressor gene (TSG) associated with brain, prostate, breast and other cancers. To test whether ANX7 might be a candidate TSG, and its role in the molecular pathogenesis of malignant glioma. We examined the ANX7 expression levels in several kinds of cell lines, 139 glioma specimens and 84 gastric cancer specimences. Consistently, analysis of ANX7 protein expression in human glioma tumor a significantly higher rate (2.14 times) of loss of ANX7 expression in glioblastoma multiformes (GBM) as compared with low grade astrocytoma (p=0.04). The striking correlation ANX7 expression and the differentiation of gastric carcinoma (p = 0.001). ANX7 may play an important role in the tumor progression. Loss or reduced expression of ANX7 is possibly a biomarker for tumor cell progression

Chapter 1.................1
Chapter 2................21
Chapter 3................50
Chapter 4................83
Chapter 5...............109
Appendix................127

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