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博碩士論文 etd-0902105-202625 詳細資訊
Title page for etd-0902105-202625
論文名稱
Title
川芎
Effect of Tetramethyl Pyrazine on Cerebral Infarct Induced by Ischemia-Reperfusion Injured in Rats
系所名稱
Department
畢業學年期
Year, semester
語文別
Language
學位類別
Degree
頁數
Number of pages
89
研究生
Author
指導教授
Advisor
召集委員
Convenor
口試委員
Advisory Committee
口試日期
Date of Exam
2005-06-07
繳交日期
Date of Submission
2005-09-02
關鍵字
Keywords
川芎、腦梗塞效、缺血-再灌流
tumor necosis factor, interleukin-1, ischemia-reperfusion, cerebral infarct, ED1, tetramethyl pyrazine
統計
Statistics
本論文已被瀏覽 5644 次,被下載 5057
The thesis/dissertation has been browsed 5644 times, has been downloaded 5057 times.
中文摘要
根據傳統中醫理論,血瘀是造成中風的主要原因,川芎為具有活血化瘀的作用之中藥,它常被用於治療中風。川芎
Abstract
According to the theory of Traditional Chinese Medicine, the main etiology of stroke results from blood stasis. Ligustic Rhizoma (LR), a Chinese herb, is considered to stimulate stasis-dispelling. As Tetramethyl Pyrazine (TMP) is a major component of LR, the aim of the present study is to investigate the effects of TMP on cerebral infarct. We establish an animal model of cerebral infarct by occluding the both common carotid arteries and right middle cerebral artery for 90 minutes, then reperfusing for 24 hrs. Effects of TMP on cerebral infarct are evaluated by the ratio of infarction areas and modified neurologica severity scale (mNSS). In addition, we observe the changes of ED1, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) immuno-reacting cells in the infarction region. The founding indicate that pre-treatment with TMP 100 mg/kg, 120 mg/kg and 140 mg/kg, and post-treatment with TMP 100 mg/kg will decrease the ratio of cerebral infarction area and the neurological deficit. Moreover, pre-treatment TMP 100 mg/kg also decreases ED1, TNF-α and IL-1β immuno-reacting cell. In conclusion, TMP can decrease cerebral infarction area and neurological deficit. The effects of TMP, at least in part, are closely related to microglia, TNF-α and IL-1β, suggesting that TMP can be used to treat stroke in human.
目次 Table of Contents
中文摘要..………………………………………………………………i
英文摘要……………………………………………………….......ii
I. 緒論
1. 前言………………......…………………………………....1
1-1.中風……………………………………………………………………...1
1-2. 成因及分類…………………………………………….....1
1-3. 治療…………………………………………………..…...2
2. 中醫中風之源流及治療…….……………………..……….. ..3
2-1. 中醫中風之源流 …………………………………………….3
2-2. 中風的中醫療法 ……………..…………………………….5
2-3. 活血化瘀藥的要理作用 ………………………………….. 5
3. 文獻探討.………………………………………………….......6
3-1 川芎之功用及藥理作用 ……………..………………………..6
3-2 川芎
參考文獻 References
參考文獻
1. 立得中醫研究室, 活血化淤的研究, 立得出版社, 台北市。 pp.431(1994)
2. 行政院衛生署網站資料: 台灣地區主要死亡原因-91年
3. 沈映君、徐秋萍、陳奇、李岳, 中藥藥理學, 人民衛生出版社, 北京市。pp.629-641(2000)
4. 林麗娜、王萬鐵、徐正禎、李東,川芎
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