本研究提出近場靜電紡絲技術 (Near-field electrospinning, NFES) 應用在生物可相容聚胜肽型壓電纖維的開發，其主要由蜘蛛絲 (Spider silk) 內的聚胜肽 (Polypeptide) 壓電特性 (Piezoelectric properties) 啟發及驗證，藉由結合近場靜電紡製作聚偏氟乙烯 (Poly (vinylidene fluoride), PVDF) 壓電纖維 (Piezoelectric fibers)的 44 μS/cm電紡溶液電導率、1.60×10^7 V/m電場、1 mm收集間距、0.50 ml/hr溶液推進速率與收集裝置2618.10 mm/s切線速度的穩定參數，電紡出聚谷氨酸苄酯 (Poly (γ-benzyl α L-glutamate), PBLG)與聚谷氨酸甲酯 (Poly (γ-methyl l-glutamate), PMLG) 的聚胜肽壓電纖維，並透過微拉伸實驗 (Micro tensile testing) 、傅立葉紅外光譜 (Fourier Transform Infrared Spectroscopy, FTIR) 及電性 (Electricity properties) 的量測，最後混摻出具有高壓電特性且可生物相容性之PMLG/PVDF的聚生肽纖維。實驗結果證實蜘蛛絲經由極化後會使聚胜肽中二級結構的α-螺旋 (α-helix) 與β-折板 (β-sheet) 分子結構形成有序的排列，可以得到4 Hz電性量測下輸出40.70 mV電壓訊號與105 nA電流訊號，並從近場靜電紡絲實驗中建立出的穩定製成參數亦可分別成功的製作出純料PBLG、PMLG，以及混摻PMLG/PVDF的聚胜肽壓電纖維，其於相較之下混摻PMLG/PVDF聚胜肽纖維的壓電特性大於純料的PBLG與PMLG，最大可輸出115 mV的電壓與173 nA的電流，且於8 MΩ負載下，即獲得722 pW的最大功率輸出。

This study presents polypeptide piezoelectric fibers with biocompatibility by near-field electrospinning (NFES), which is inspired by the polypeptide of spider silk initially. Poly (γ-benzyl α L-glutamate) (PBLG) fiber and Poly (γ-methyl l-glutamate) (PMLG) fiber are obtained by NFES. Parameters of PBLG and PMLG fiber process are based on Poly (vinylidene fluoride) (PVDF) fiber where electrospinning solution conductivity is 44 μS/cm, electric field is 1.60×10^7 V/m, collecting gap is 1 mm, speed rate of infusion pump is 0.50 ml/hr, and tangent speed of collecting device is 2618.10 mm/s. Moreover, the blends of PMLG/PVDF with biocompatibility are obtained. Micro tensile testing, Fourier transform infrared spectroscopy (FTIR), and electricity test of the blends of PMLG/PVDF are carried out. The results show that spider silk after polarization was made to have α-helix and β-sheet of secondary structure with orderly arrangement. The open circuit voltage and close loop current of spider silk are 40.70 mV and 105 nA, respectively. The blends of PMLG/PVDF with high piezoelectric effect are fabricated successfully. The maximum open circuit voltage and close loop current of PMLG/PVDF fiber are reached to 115 mV and 173 nA, respectively. The output power of PMLG/PVDF fiber under 8 MΩ is 722 pW.

致謝 i
摘要 ii
Abstract iii
目錄 iv
圖目錄 vii
表目錄 xi
第一章 緒論 1
1.1 前言 1
1.2 研究動機 9
1.3 研究目的 9
1.4 論文架構 10
第二章 文獻回顧 11
2.1 壓電效應 11
2.1.1正逆壓電效應 12
2.2 壓電材料 13
2.3 PVDF壓電材料 14
2.4聚胜肽 17
2.5 聚胜肽中氫鍵與壓電特性之關係 19
2.6 電紡製程技術 23
第三章 研究方法與步驟 26
3.1 天然聚胜肽的蜘蛛絲抽絲 27
3.2 PVDF電紡溶液配置與溶液電導率之量測 29
3.2.1 PVDF電紡溶液配置 29
3.2.2 PVDF電紡溶液電導率之量測 30
3.3 PBLG、PMLG與PVDF/PMLG混摻聚胜肽之電紡溶液配置 32
3.3.1 PBLG聚胜肽材料之電紡溶液配置 32
3.3.2 PMLG聚胜肽材料之電紡溶液配置 33
3.3.3 PVDF/PMLG混摻聚胜肽材料之電紡溶液配置 34
3.4 近場靜電紡製程與設備 36
3.5 蜘蛛絲與近場靜電紡之纖維性質量測 38
3.5.1表面特徵量測 38
3.5.2材料特性量測 39
3.5.2機械性質量測 41
3.6 電能擷取片製作與電性量測 42
第四章 結果與討論 46
4.1天然胜肽的蜘蛛絲特性探討 46
4.1.1 取絲速率與絲線徑之關係 46
4.1.2 蜘蛛絲機械特性探討 47
4.1.3 蜘蛛絲未極化與極化之材料特性探討 48
4.1.3 蜘蛛絲電特性量測 50
4.2 近場靜電紡之製程參數與PVDF壓電纖維特性關係探討 54
4.2.1電場強度與PVDF壓電纖維的線徑關係 54
4.2.2收集裝置的切線速度與PVDF壓電纖維的線徑關係 55
4.2.3 PVDF壓電纖維的機械特性探討 56
4.2.4 PVDF壓電纖維的材料性質探討 57
4.2.5 PVDF壓電纖維的電特性探討 58
4.3 純PBLG、PMLG聚胜肽壓電纖維探討 60
4.3.1聚胜肽壓電纖維機械特性 60
4.3.2聚胜肽壓電纖維材料特性 62
4.3.3聚胜肽壓電纖維電特性 64
4.4 PMLG/PVDF混摻之聚胜肽壓電纖維探討 67
4.4.1材料特性探討 67
4.4.2機械特性探討 69
4.4.3 PMLG/PVDF混摻之聚胜肽壓電纖維電特性探討 70
第五章 結論與未來展望 72
參考文獻 74

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