Title page for etd-0905111-173638


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URN etd-0905111-173638
Author Wei-Hua Chen
Author's Email Address x_x1224@yahoo.com.tw
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Department Marine Biotechnology and Resources
Year 2010
Semester 2
Degree Master
Type of Document
Language zh-TW.Big5 Chinese
Title Studies on Secondary Metabolites from the Bamboo Coral Isis hippuris
Date of Defense 2011-06-18
Page Count 283
Keyword
  • Isis hippuris
  • cytotoxicity
  • polyoxygenated steroids
  • anti-HCMV
  • secondary metabolites
  • Abstract Previous studies on the secondary metabolites of Formosan octocoral Isis hippuris were collected only at Green Island. In the course of our studies on secondary metabolites from marine organisms, the acetone-solubles of the Formosan octocoral Isis hippuris collected at Orchid Island has led to the isolation of eleven polyoxygenated steroids (1–11), along with two known compounds (12 and 13). The structures of these compounds were determined on the basis of their spectroscopic and physical data, including NMR, IR, MS, etc. The cytotoxicity against of A-549 (human lung epithelial carcinoma), HT-29 (human colon adenocarcinoma), and P-388 (mouse lymphocytic leukemia) cells, and anti-HCMV (human cytomegalovirus) activity of metabolites 1–13 were evaluated. Compounds 12 and 13 displayed cytotoxicity against P-388 cell line with ED50 values of 3.2 and 3.6 μg/mL, respectively. Compound 12 exhibited cytotoxicity against A-549 cell line with an ED50 value of 3.8 μg/mL. Compound 8 exhibit inhibitory activity against HCMV, with EC50 values of 2.0 μg/mL.
    Advisory Committee
  • Ling-Ching Chen - chair
  • Ian-Lih Tsai - co-chair
  • Chang-Yih Duh - advisor
  • Files
  • etd-0905111-173638.pdf
  • Indicate in-campus at 99 year and off-campus access at 99 year.
    Date of Submission 2011-09-05

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